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Updated: Feb 4, 2026
Implantation of Human-Sized Coronary Stents into Rat Abdominal Aorta Using a Trans-Femoral Access
Published on: November 19, 2020
Coronary stent implantation and adverse cardiac events after surgery
Troels Thim1, Gro Egholm1, Kevin Kris Warnakula Olesen1
1Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Insights
Procedure characteristics of drug-eluting stents did not significantly impact myocardial infarction or death risk after non-cardiac surgery. However, first-generation stents were associated with lower all-cause death risk compared to second-generation stents.
Area of Science:
- Cardiology
- Interventional Cardiology
- Surgical Risk Assessment
Background:
- Assessing non-cardiac surgery risk in patients with recent coronary stents is crucial.
- Drug-eluting stent (DES) implantation details may influence perioperative outcomes.
- Understanding these factors aids in patient management and risk stratification.
Purpose of the Study:
- To evaluate the association between DES implantation procedure characteristics and the risk of myocardial infarction (MI) and all-cause death within 30 days after non-cardiac surgery.
- To identify specific procedural factors that may increase or decrease perioperative risks.
Main Methods:
- Retrospective analysis of patients with DES identified from the Western Denmark Heart Registry.
- Detection of non-cardiac surgical procedures and adverse events (MI, all-cause death) using Danish national registries.
- Statistical analysis to assess associations between procedural characteristics and outcomes.
Main Results:
- No significant association was found between procedural characteristics (arteries/lesions treated, segments treated, stent length, number of stents, balloon diameter) and the risk of MI or all-cause death.
- A lower risk of all-cause death, but not MI, was observed with first-generation DES compared to second-generation DES.
Conclusions:
- DES implantation procedural characteristics do not appear to significantly influence the risk of MI or death within 30 days post-non-cardiac surgery.
- First-generation DES may be associated with a lower risk of all-cause death compared to second-generation DES in this context.
Background:
In the risk assessment of patients considered for non-cardiac surgery and with recent coronary stent implantation, coronary drug-eluting stent implantation procedure characteristics may be taken into account. We aimed to evaluate associations between coronary drug-eluting stent implantation procedure characteristics and the risk of myocardial infarction and all-cause death within 30 days after non-cardiac surgery.
Design:
Patients with coronary drug-eluting stents were identified using the Western Denmark Heart Registry. Surgical procedures performed after stent implantation were detected using the Danish National Patient Registry. We used registry-based detection of myocardial infarction and all-cause death.
Results:
Of 22 590 patients treated with drug-eluting stents between 2005 and 2012, 4046 underwent non-cardiac surgery within 1 and 12 months after stent implantation. We found no significant association between the risk of myocardial infarction or all-cause death within 30 days after surgery and number of arteries treated (1 [reference] vs more), number of lesions treated (1 [reference] vs more), segments treated (left main and proximal left anterior descending artery vs other [reference]), total stent length (<20 mm [reference] vs ≥20 mm), number of stents (1 [reference] vs >1) and largest balloon diameter (≥3 mm [reference] vs <3 mm). All-cause death, but not myocardial infarction, risk was lower among patients treated with first-generation vs second-generation stents (odds ratio 0.58).
Conclusions:
We identified no significant associations between stent implantation procedure characteristics and risk of myocardial infarction or all-cause death among patients undergoing non-cardiac surgery. All-cause death was lower with first- vs second-generation drug-eluting stents.
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