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Necrotizing fasciitis caused by Mucor indicus in a pediatric bone marrow transplant recipient

Deborah Bloch1, Mark D Gonzalez2, Ann Haight3

  • 1Department of Pediatric Infectious Diseases, Emory University, Atlanta, Georgia.

Pediatric Transplantation
|September 25, 2018
PubMed

Insights

Necrotizing fasciitis, a severe bacterial infection, can rarely be caused by the fungus Mucor indicus, especially in immunocompromised children. This case highlights the diagnostic challenges and prolonged treatment required for this rare fungal infection.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Immunocompromised Hosts

Background:

  • Necrotizing fasciitis is a severe soft tissue infection, typically polymicrobial.
  • Fungal causes are rare, posing diagnostic and therapeutic challenges.

Observation:

  • A 4-year-old immunocompromised female presented with necrotizing fasciitis.
  • The causative agent was identified as Mucor indicus, a rare fungal pathogen.

Findings:

  • The patient required extensive surgical debridement.
  • Treatment involved prolonged antifungal therapy with liposomal amphotericin B and posaconazole for 10 months.

Implications:

  • Highlights the potential for rare fungal pathogens like Mucor indicus to cause severe infections.
  • Emphasizes the need for improved diagnostic methods and understanding of risk factors for Mucor indicus infections.
  • Underscores the importance of susceptibility testing to guide effective antifungal treatment strategies.
Keywords:
Mucor indicusMucoralesbone marrow transplantationnecrotizing fasciitis

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