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Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10
Published on: November 19, 2016
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Bet v 1 sensitization modulates allergenic molecular immune response
G Ciprandi1, M Silvestri2, A Pistorio3
1Ospedale Policlinico San Martino, Genoa, Italy.
European Annals of Allergy and Clinical Immunology
|September 25, 2018
Summary
Bet v 1 sensitization significantly impacts allergy profiles in children. Children sensitized to Bet v 1, a major PR-10 allergen, show broader sensitization patterns to other allergens.
Area of Science:
- Immunology
- Allergology
- Pediatrics
Background:
- Allergy diagnosis relies on identifying allergen-specific immunoglobulin E (IgE).
- Molecular diagnostics refine allergy profiles by pinpointing specific sensitizations.
- Bet v 1, a prominent PR-10 family allergen, and the role of pan-allergens in adult sensitization are known.
Purpose of the Study:
- To investigate the influence of Bet v 1 sensitization on the overall sensitization pattern in a large pediatric cohort.
- To assess the cross-reactivity and broader sensitization implications associated with Bet v 1 in children.
Main Methods:
- Serum IgE levels against molecular allergy components were analyzed using the ISAC method.
- Data from 1,205 children (median age 8.61 years) were evaluated.
- Subjects were categorized based on sensitization to Bet v 1 and other PR-10 family molecules.
Main Results:
- Out of 1,205 children, 354 (29.4%) tested positive for PR-10 sensitization.
- Bet v 1-positive children exhibited significantly higher rates of sensitization to other PR-10 family molecules.
- A notable increase in sensitization to unrelated allergenic families was observed in Bet v 1-positive children.
Conclusions:
- Bet v 1 sensitization is a significant factor influencing the allergic sensitization pattern in children.
- This effect is evident even in geographic areas without birch trees, such as Genoa.
- Molecular allergy diagnostics are crucial for understanding complex sensitization profiles in pediatric populations.
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