Related Experiment Video

Updated: Feb 4, 2026

Reprograming Model of Human Monocyte-derived Macrophages for In-vitro Assays
08:37

Reprograming Model of Human Monocyte-derived Macrophages for In-vitro Assays

Published on: April 18, 2025

1.1K

Soluble CD163 Levels and CD163+CD14+ Monocyte/Macrophage Counts in Patients with Asthma

Yue Zhi1, Peng Gao, Wei Li

  • 1Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Jilin University, Changchun, Jilin, China.

Iranian Journal of Immunology : IJI
|September 25, 2018
PubMed
Abstract

Insights

Soluble CD163 (sCD163) levels in sputum are elevated in asthma patients, particularly severe cases. This increase in sCD163 correlates with impaired lung function, suggesting its role in asthma pathogenesis.

Area of Science:

  • Immunology
  • Respiratory Medicine
  • Biomarker Discovery

Background:

  • CD163-expressing macrophages play a role in the inflammatory processes characteristic of asthma.
  • Understanding the involvement of specific macrophage markers can provide insights into asthma pathophysiology.

Purpose of the Study:

  • To evaluate sputum and serum soluble CD163 (sCD163) levels in asthma patients.
  • To compare sCD163 levels with classic inflammatory mediators.
  • To investigate the relationship between sCD163 and asthma severity.

Main Methods:

  • Sputum induction and collection from 85 asthma patients and 21 healthy controls.
  • Measurement of sputum and serum soluble CD163 (sCD163) and various interleukins (IL-4, IL-5, IL-1β, IL-8, IL-9, IL-6).
  • Flow cytometry analysis of CD163+ monocytes in peripheral blood.

Main Results:

  • Sputum sCD163 levels were significantly higher in asthma patients compared to healthy controls (P<0.001).
  • Both sputum and serum sCD163 levels were elevated in severe asthma compared to mild/moderate asthma (P=0.020 and P=0.032, respectively).
  • The percentage of CD163+ monocytes was lower in asthma patients than in controls (P<0.001).

Conclusions:

  • Elevated sputum sCD163 levels are associated with impaired lung function in asthma.
  • sCD163 may serve as a potential biomarker for asthma severity and progression.

More Related Videos

Differentiation of Monocytes into Phenotypically Distinct Macrophages After Treatment with Human Cord Blood Stem Cell CB-SC-Derived Exosomes09:20

Differentiation of Monocytes into Phenotypically Distinct Macrophages After Treatment with Human Cord Blood Stem Cell CB-SC-Derived Exosomes

Published on: November 12, 2020

6.3K
Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes11:52

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

Published on: January 27, 2023

4.5K

Related Concept Videos

Factors Affecting Solubility04:01

Factors Affecting Solubility

Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
37.2K
Solubility Equilibria03:07

Solubility Equilibria

Solubility equilibria are established when the dissolution and precipitation of a solute species occur at equal rates. These equilibria underlie many natural and technological processes, ranging from tooth decay to water purification. An understanding of the factors affecting compound solubility is, therefore, essential to the effective management of these processes. This section applies previously introduced equilibrium concepts and tools to systems involving dissolution and precipitation.
The...
57.5K
Solubility of Ionic Compounds02:55

Solubility of Ionic Compounds

Solubility is the measure of the maximum amount of solute that can be dissolved in a given quantity of solvent at a given temperature and pressure. Solubility is usually measured in molarity (M) or moles per liter (mol/L). A compound is termed soluble if it dissolves in water.
68.2K
Physical Properties Affecting Solubility02:19

Physical Properties Affecting Solubility

Solutions of Gases in Liquids
As for any solution, the solubility of a gas in a liquid is affected by the attractive intermolecular forces between solute and solvent species. Unlike solid and liquid solutes, however, there is no solute-solute intermolecular attraction to overcome when a gaseous solute dissolves in a liquid solvent since the atoms or molecules comprising a gas are far separated and experience negligible interactions. Consequently, solute-solvent interactions are the sole...
26.6K
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.5K
Solubility03:00

Solubility

Solution, Solubility, and Solubility Equilibrium
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules,...
21.2K