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Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors
Published on: July 16, 2012
No effect of MTP polymorphisms on PNPLA3 in HCV-correlated steatosis
Rosa Zampino1, Margherita Macera2, Grazia Cirillo3
1Department of Medical, Surgical, Neurological, Metabolic and Aging Science, University of Campania "Luigi Vanvitelli", Italy.
Abstract:
PNPLA3 and MTP genes have been associated with liver steatosis and chronic hepatitis C. We studied the influence of MTP and PNPLA3 polymorphisms in 114 Italian patients with chronic hepatitis C, evaluating the histological and clinical presentation of liver disease. The study confirmed the association of PNPLA3 polymorphisms with liver steatosis (p=0.041), but did not show any additive effect of MTP polymorphisms in the development of steatosis. MTP polymorphisms do not seem to influence PNPLA3 in the development of liver steatosis. Further studies with a larger number of patients are required.
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