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Updated: Feb 4, 2026

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
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Deep and Durable Response With Combination CTLA-4 and PD-1 Blockade in Mismatch Repair (MMR)-proficient Endometrial

Michael S Oh1, Young Kwang Chae1,2

  • 1Northwestern University Feinberg School of Medicine.

Journal of Immunotherapy (Hagerstown, Md. : 1997)
|September 25, 2018
PubMed

Insights

This case study highlights a patient with advanced endometrial cancer who responded well to immune checkpoint inhibitors, even without typical biomarkers like MMR deficiency or PD-L1 positivity. Further research is needed to understand immunotherapy responses in this cancer type.

Area of Science:

  • Oncology
  • Immunology
  • Cancer Research

Background:

  • Immune checkpoint inhibitors (ICIs) like PD-1 and CTLA-4 blockers are effective cancer treatments.
  • Biomarkers such as mismatch repair (MMR) deficiency and PD-L1 positivity predict ICI response in various cancers.
  • The efficacy of immunotherapy in endometrial cancer is not fully understood.

Observation:

  • A patient with stage IV endometrial cancer, who was MMR-proficient and PD-L1-negative, received combination PD-1 and CTLA-4 inhibition (nivolumab and ipilimumab).
  • The patient experienced a significant and durable partial response lasting over 12 months.

Findings:

  • This case suggests that some endometrial cancers may respond to ICIs through mechanisms independent of MMR deficiency or PD-L1 expression.
  • The patient's response indicates a potential novel subtype of endometrial cancer sensitive to immune checkpoint blockade.

Implications:

  • This finding broadens the potential application of immunotherapy in endometrial cancer.
  • Further investigation into immunotherapy response mechanisms in advanced endometrial cancer is crucial for improving patient outcomes.
  • Identifying new predictive biomarkers for immunotherapy in endometrial cancer is warranted.

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