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Updated: Feb 4, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
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Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

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Umbilical Cord Hepcidin Concentrations Are Positively Associated with the Variance in Iron Status among Multiple

Yuan Ru1, Eva K Pressman2, Ronnie Guillet2

  • 1Division of Nutritional Sciences, Cornell University, Ithaca, NY.

The Journal of Nutrition
|September 25, 2018
PubMed

Insights

Fetal hepcidin, not maternal, significantly influences neonatal iron status and related indicators. This study highlights fetal hepcidin

Area of Science:

  • Neonatal physiology
  • Iron metabolism
  • Maternal-fetal medicine

Background:

  • Hepcidin regulates systemic iron homeostasis.
  • The distinct roles of maternal versus cord hepcidin in neonatal iron regulation are not well understood.

Purpose of the Study:

  • To investigate intrauterine and inter-sibling variations in neonatal iron status, vitamin B12, folate, and inflammatory markers.
  • To determine the relative influence of maternal and fetal hepcidin on neonatal iron homeostasis.

Main Methods:

  • Analysis of umbilical cord blood from 144 neonates from multiple births (twins, triplets, quadruplets).
  • Measurement of cord hemoglobin, ferritin, soluble transferrin receptor, hepcidin, erythropoietin, iron, vitamin B12, folate, and inflammatory markers.
  • Intraclass correlation coefficient (ICC) analysis to assess variance.

Main Results:

  • Cord hepcidin showed greater variability between siblings (ICC=0.39) and significantly impacted intrauterine variance in hemoglobin, ferritin, sTfR, and EPO.
  • Maternal hepcidin did not affect cord iron indicators.
  • Differences in cord ferritin, sTfR, hepcidin, and EPO were greater between di-/trichorionic siblings compared to monochorionic siblings.

Conclusions:

  • Fetal-derived hepcidin appears to be a primary regulator of intrauterine iron status, independent of maternal hepcidin.
  • Multiple birth models offer a unique approach to studying factors influencing placental nutrient transport and iron stores at birth.
Abstract

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