Changes in interaction of bovine dentin phosphophoryn with calcium and hydroxyapatite by chemical modifications

Dentin phosphophoryn was found to lose its precipitability with calcium ion when dephosphorylated or carboxylate-blocked, whereas precipitation of the intact protein was induced at calcium concentration as low as 2 mM. On the other hand, the adsorption capacity of phosphophoryn onto the hydroxyapatite surface increased when acidic groups were diminished by the above modifications.