Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacodynamics: Overview and Principles01:21

Pharmacodynamics: Overview and Principles

3.3K
Pharmacodynamics is a scientific field that delves into drugs' intricate biochemical, cellular, and physiological effects on the human body. The study of pharmacodynamics helps us understand how drugs interact with the body and elicit various responses.
Most drugs' effects result from their interactions with drug receptors or targets within the body. These interactions trigger specific responses at the cellular or systemic level. Drug receptors can be found on the surfaces of cells or...
3.3K
Measurement of Bioavailability: Pharmacodynamic Methods01:20

Measurement of Bioavailability: Pharmacodynamic Methods

772
Pharmacodynamic methods provide insights into a drug's effects on physiological processes over time and play a crucial role in understanding bioavailability and therapeutic efficacy. These methods can be broadly classified into acute pharmacological and therapeutic response approaches, each with distinct mechanisms and applications.The acute pharmacological response method directly correlates a drug's physiological effects, such as ECG or pupil diameter changes, to its time course in the body.
772
Introduction to Developmental Psychology01:27

Introduction to Developmental Psychology

1.6K
Developmental psychology explores the changes and continuities in human abilities throughout life, encompassing physical, cognitive, linguistic, and social dimensions. Human development is not restricted to growth, but includes aspects of decline, particularly in physical abilities as individuals age. Developmental psychologists seek to understand how people change as they age and how their mental and social skills evolve.Developmental MilestonesA key concept in developmental psychology is...
1.6K
Three Developmental Domains01:29

Three Developmental Domains

1.1K
Human development is typically examined across three main domains: physical, cognitive, and socio-emotional. These domains represent the significant areas of change and continuity throughout the lifespan, from infancy to late adulthood.
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and weight,...
1.1K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

238
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
238
Pharmacokinetics: Overview01:10

Pharmacokinetics: Overview

9.6K
Pharmacokinetics is a scientific discipline that focuses on the journey of a drug within the body, encompassing four key stages: absorption, distribution, metabolism, and elimination. The first stage, absorption, involves the drug's transfer into the bloodstream. Several factors dictate the extent and speed of this process. For example, the liver often metabolizes oral drugs before they reach systemic circulation, leading to only partial absorption. In contrast, intravenous (IV)...
9.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Commentary on "Examining the Evidence Around Acetaminophen and Autism Risk".

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG·2026
Same author

Development and application of a CNS PBPK model that integrates CSF dynamics to optimize dosing regimens of antibacterial agents in pediatric patients with meningitis.

International journal of antimicrobial agents·2026
Same author

Brain activity as a candidate biomarker for personalised caffeine treatment in premature neonates.

Frontiers in pediatrics·2026
Same author

Machine Learning Prediction of Unbound Ceftriaxone Concentrations in Children: Capturing Developmental Changes in Protein Binding for Precision Dosing.

Clinical pharmacology and therapeutics·2026
Same author

Electroencephalography during acute painful procedures in neonates: a scoping review.

Pain reports·2026
Same author

The Pharmacokinetics and Relative Bioavailability of a Mini-Tablet of Mercaptopurine, a Novel Formulation for Use in Children with Acute Lymphoblastic Leukemia.

Journal of clinical pharmacology·2026

Related Experiment Video

Updated: Feb 4, 2026

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice
08:41

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice

Published on: October 27, 2014

23.9K

Developmental Changes in Pharmacokinetics and Pharmacodynamics.

John van den Anker1,2,3, Michael D Reed4, Karel Allegaert3,5,6

  • 1Division of Clinical Pharmacology, Children's National Health System, Washington, DC, USA.

Journal of Clinical Pharmacology
|September 25, 2018
PubMed
Summary

Understanding how a child's age affects drug absorption, distribution, metabolism, excretion, and receptor dynamics is crucial for effective pediatric pharmacotherapy. Further research is needed to model these age-related drug disposition characteristics accurately.

Keywords:
developmental pharmacologydrug transportersdrug-metabolizing enzymespediatric pharmacologypharmacodynamicspharmacokinetics

More Related Videos

Intraventricular Drug Delivery and Sampling for Pharmacokinetics and Pharmacodynamics Study
09:18

Intraventricular Drug Delivery and Sampling for Pharmacokinetics and Pharmacodynamics Study

Published on: March 31, 2022

3.0K
A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
07:02

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

Published on: February 11, 2019

10.3K

Related Experiment Videos

Last Updated: Feb 4, 2026

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice
08:41

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice

Published on: October 27, 2014

23.9K
Intraventricular Drug Delivery and Sampling for Pharmacokinetics and Pharmacodynamics Study
09:18

Intraventricular Drug Delivery and Sampling for Pharmacokinetics and Pharmacodynamics Study

Published on: March 31, 2022

3.0K
A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
07:02

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

Published on: February 11, 2019

10.3K

Area of Science:

  • Pharmacology
  • Pediatric Medicine
  • Drug Metabolism

Background:

  • Effective drug therapy necessitates understanding pharmacokinetic, pharmacodynamic, and pharmacogenomic interrelationships.
  • Pediatric patients exhibit significant variability in drug disposition and effect due to age-related continuum.
  • Current understanding of age-related drug disposition in children is incomplete.

Purpose of the Study:

  • To address factors influencing drug disposition and effect in relation to age in pediatric patients.
  • To outline current knowledge on maturation's influence on drug absorption, distribution, metabolism, excretion, and receptor dynamics.
  • To highlight the need for further research in pediatric pharmacokinetics.

Main Methods:

  • Review of existing literature on pediatric pharmacokinetics and pharmacodynamics.
  • Analysis of age-dependent changes in drug absorption, distribution, metabolism, and excretion.
  • Examination of drug receptor dynamics across the pediatric age continuum.

Main Results:

  • Maturation significantly impacts drug absorption, distribution, metabolism, and excretion processes in children.
  • Drug receptor dynamics also exhibit age-related variations.
  • Significant gaps in understanding pediatric drug disposition remain.

Conclusions:

  • Enhanced understanding of age-related drug disposition is essential for optimizing pediatric pharmacotherapy.
  • Further research is required to accurately model drug-response relationships across the pediatric age continuum.
  • Improved knowledge will enhance care for ill pediatric patients and inform new drug development.