The impact of motor impairment on the processing of sensory information

Sensorimotor adaptation is driven by mismatch errors between desired movements and actual movement outcomes. A mismatch error can be minimized by adjusting movements or by altering the interpretation of sensory information. While the effect of mismatch errors on the motor system has received much attention, the contribution of somatosensory feedback, particularly the sensory-motor interplay in the process of adaptation, remains poorly understood. Our study analyzes the impact of peripheral deefferentation on the plasticity of the brain networks responsible for sensory-motor adaptation, focusing particularly on changes in the processing of somatosensory information. For this aim, task-based and resting-state functional MRI was performed on 24 patients in the acute state of a left-sided idiopathic peripheral facial nerve palsy. The functional connectivity of cortical and subcortical networks was analyzed and compared to a healthy control group. We found a strong involvement of the somatosensory system and the thalamus in the adaptation process following an acute peripheral deefferentation. The investigated network shows the principal pattern of a reduced connectivity between cortical areas, while the connectivity to subcortical areas (the basal ganglia and the thalamus) is increased. We suggest that the increased connectivity between the subcortical and cortical structures indicates an active sensory-motor adaptation process. We further hypothesize that the decreased functional connectivity at the cortical level reflects an unsuccessful sensorimotor adaptation process due to the inability to solve the somatosensory-motor mismatch. These results extend our understanding of the somatosensory-motor interaction in response to a mismatch signal and highlight the importance of the thalamus in this process.