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Microbiota - an amplifier of autoimmunity
Alexis Vogelzang1, Matteo M Guerrini1, Nagahiro Minato2
1Laboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Tsurumi Ward, Suehirocho, 1 Chome-7-22, Yokohama, Kanagawa Prefecture, 230-0045, Japan.
Current Opinion in Immunology
|September 25, 2018
Summary
The immune system and gut microbiota have a two-way relationship influencing autoimmune diseases. Understanding this connection is key to developing new treatments for these conditions.
Area of Science:
- Immunology
- Microbiology
- Gastroenterology
Background:
- Dysbiosis, or microbial imbalance, is frequently observed in autoimmune diseases.
- The role of dysbiosis as a cause or consequence of altered immunity remains unclear.
- The immune system actively influences gut microbiota composition.
Purpose of the Study:
- To investigate the bidirectional relationship between the immune system and gut microbiota.
- To explore how this interaction contributes to the development and progression of autoimmune diseases.
Main Methods:
- Review of existing literature on the immune system-microbiota axis in autoimmunity.
- Analysis of mechanisms by which immune dysregulation impacts microbiota.
- Examination of how microbiota alterations affect immune function and autoimmunity.
Main Results:
- The immune system shapes the microbiota, with different outcomes in healthy versus autoimmune-prone individuals.
- The gut microbiota functions as an acquired endocrine organ, influencing host physiology.
- Immune-driven dysbiosis can initiate or exacerbate autoimmune conditions.
Conclusions:
- The interplay between the immune system and gut microbes is a critical factor in autoimmune diseases.
- Targeting this bidirectional relationship may offer therapeutic strategies for autoimmune disorders.
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