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Related Concept Videos

Protein Networks02:26

Protein Networks

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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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Protein-protein Interfaces02:04

Protein-protein Interfaces

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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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Protein and Protein Structure02:15

Protein and Protein Structure

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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
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Protein Complex Assembly02:41

Protein Complex Assembly

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Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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What are Viruses?00:50

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Detecting Virus and Salivary Proteins of a Leafhopper Vector in the Plant Host
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Viruses.STRING: A Virus-Host Protein-Protein Interaction Database.

Helen Victoria Cook1, Nadezhda Tsankova Doncheva2,3, Damian Szklarczyk4

  • 1Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, DK-2200 Copenhagen N, Danmark. helen.cook@gmail.com.

Viruses
|September 26, 2018
PubMed
Summary
This summary is machine-generated.

Understanding virus-host protein interactions is crucial for developing new treatments and vaccines. The new Viruses.STRING database offers a comprehensive resource for exploring these vital viral and host protein connections.

Keywords:
PPI databaseprotein–protein interactionsvirus bioinformaticsvirus–host interactions

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Area of Science:

  • Virology
  • Bioinformatics
  • Immunology

Background:

  • Viruses pose significant global health risks, necessitating a deeper understanding of their interactions with host organisms.
  • Virus-host protein-protein interactions are key targets for therapeutic and vaccine development.

Purpose of the Study:

  • To introduce Viruses.STRING, a novel database focused on virus-virus and virus-host protein-protein interactions.
  • To provide a centralized resource for researchers studying viral pathogenesis and host responses.

Main Methods:

  • The database integrates evidence from experimental data and automated text-mining.
  • Interaction probabilities are calculated by combining diverse evidence sources.

Main Results:

  • Viruses.STRING contains 177,425 interactions involving 239 viruses and 319 host organisms.
  • The database provides combined probabilities for protein-protein interactions.

Conclusions:

  • Viruses.STRING serves as a valuable public resource for the scientific community.
  • The database facilitates research into virus-virus and virus-host interactions, aiding in the development of countermeasures against viral diseases.