Related Experiment Video
Updated: Feb 4, 2026

Shuttle Box Assay as an Associative Learning Tool for Cognitive Assessment in Learning and Memory Studies using Adult Zebrafish
Published on: July 12, 2021
Association between cognitive function and life-space mobility in older adults: results from the FRéLE longitudinal
François Béland1,2,3, Dominic Julien4,5,6, Nathalie Bier7,8
1Groupe de recherche Solidage, CSSS de la Montagne, site Metro, 1801, boulevard de Maisonneuve Ouest, bureau 600, Montréal, Québec, H3H 1J9, Canada. francois.beland@umontreal.ca.
Background:
Cross-sectional and longitudinal studies show conflicting results regarding the association between cognition and life-space mobility, and little is known regarding the mediators and moderators of the association. The aim of this study was to investigate the association between cognition and life-space mobility in older adults, as well as the intervening variables modifying the relationship.
Methods:
Community-dwelling older adults aged 65 years and older (N = 1643) were assessed at three time points over a period of 2 years. Growth mixture models with mediation and moderation analysis were utilised to investigate association between cognitive function and life-space mobility. The potential mediators and moderators were depressive symptoms, locus of control, gait speed and grip strength. Analysis was controlled for age, sex, education, annual income, number of chronic illnesses, and living site.
Results:
The direct association between initial scores of cognitive function and life-space was mediated by initial scores of depressive symptoms and gait speed, and moderated by initial scores of grip strength. No direct association between change in cognitive function and change in life-space mobility was found; the scores were mediated by change in depressive symptoms.
Conclusions:
We conclude that the relationship between change in cognitive function and life-space mobility in older adults is not well-defined over an observation period of 2 years.
Related Concept Videos
Functions of Life
Metabolism
The basic function of an organism is to consume energy and molecules in foods, convert some of it into fuel for movement, sustain body functions, and build and maintain body structures. There are two types of reactions that accomplish this: anabolism and catabolism.
Anabolism is the process whereby...
Longitudinal Studies
Transfer Function to State Space
In an RLC...
State Space to Transfer Function
The transformation process begins with the state-space representation, characterized by the state equation and the output equation. These equations are typically represented as:
Cognitive Dissonance
Longitudinal Research

