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Metabolomic alterations associated with Behçet's disease
Wenjie Zheng1, Xiuhua Wu2,3, Maryam Goudarzi4
1Department of Rheumatology and Clinical Immunology, Key Laboratory of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Ministry of Education, Beijing, China. wenjzheng@gmail.com.
Arthritis Research & Therapy
|September 26, 2018
Summary
Serum linoleic acid (LA) and arachidonic acid (AA) levels are significantly altered in Behçet
Area of Science:
- Metabolomics
- Lipidomics
- Biomarker Discovery
Background:
- Behçet's disease (BD) diagnosis is challenging due to a lack of specific biomarkers.
- Identifying reliable diagnostic markers is crucial for early and accurate diagnosis of BD.
Purpose of the Study:
- To identify potential serum metabolites associated with Behçet's disease.
- To evaluate the diagnostic potential of identified metabolites for BD and its disease activity.
Main Methods:
- Serum samples from BD patients and healthy controls (HC) underwent metabolomics and lipidomics profiling.
- UPLC-QTOF-MS and UPLC-QTOF-MSE techniques were employed for comprehensive analysis.
- Validation in an independent cohort included disease controls (RA, SLE, TA, CD) and ROC analysis.
Main Results:
- Metabolomic profiles clearly distinguished BD patients from HC.
- Lower phosphatidylcholine (PC) levels and higher polyunsaturated fatty acid (PUFA) levels were observed in BD patients.
- Serum linoleic acid (LA) and arachidonic acid (AA) levels were significantly elevated in BD patients compared to HC and disease controls.
Conclusions:
- Serum metabolomic profiles are significantly altered in Behçet's disease patients.
- Serum linoleic acid (LA) and arachidonic acid (AA) show promise as diagnostic biomarkers for BD.
- These omega-6 PUFAs demonstrate good sensitivity and specificity in differentiating BD patients.