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Related Concept Videos

Types of Fever01:25

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The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment
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Neonatal fever: A puzzling case.

S Bonnet Ducrot1, D Plantaz2, N Mathieu3

  • 1Neonatal Intensive Care Unit, Grenoble Alpes University, CS10217, Grenoble University Hospital, 38043 Grenoble, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|September 26, 2018
PubMed
Summary
This summary is machine-generated.

Maternal toxoplasmosis during pregnancy can harm fetuses. This case highlights reactivation due to immunosuppression, leading to congenital toxoplasmosis with unique symptoms like reversible B lymphopenia in the infant.

Keywords:
Congenital toxoplasmosisLymphopeniaNeonatal fever

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Area of Science:

  • Immunology
  • Infectious Diseases
  • Maternal-Fetal Medicine

Background:

  • Toxoplasmosis is a significant risk during pregnancy, potentially causing fetal infection.
  • Management and follow-up protocols for toxoplasmosis in pregnancy differ globally.
  • Congenital toxoplasmosis arises from maternal infection during gestation.

Observation:

  • A case of congenital toxoplasmosis with atypical presentation and pathophysiology is detailed.
  • The mother had prior toxoplasmosis immunization but underwent immunosuppressive therapy for Crohn disease during pregnancy.
  • This immunosuppression may have triggered toxoplasmosis reactivation in the mother.

Findings:

  • The reactivation led to congenital toxoplasmosis in the fetus.
  • The affected infant exhibited reversible B lymphopenia, a decrease in B lymphocytes.
  • The infant also presented with hypogammaglobulinemia, characterized by low levels of immunoglobulins.

Implications:

  • This case underscores the risk of toxoplasmosis reactivation in immunocompromised pregnant individuals.
  • It highlights the importance of considering immunosuppressive therapy's role in pregnancy-related infections.
  • The findings suggest potential immune dysregulation in infants with congenital toxoplasmosis, requiring further investigation.