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Related Experiment Video

Updated: Feb 4, 2026

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The PD-1 rs36084323 A > G polymorphism decrease cancer risk in Asian: A meta-analysis.

Liang-Shan Da1, Ying Zhang2, Cong-Jun Zhang1

  • 1Department of Medical Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China.

Pathology, Research and Practice
|September 26, 2018
PubMed
Summary
This summary is machine-generated.

The PD-1 rs36084323 A>G polymorphism is not linked to overall cancer risk. However, this genetic variation is associated with reduced cancer risk in Asian populations and ovarian cancer patients.

Keywords:
CancerMetaPD-1Polymorphism

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Area of Science:

  • Genetics
  • Oncology
  • Immunology

Background:

  • The programmed cell death-1 (PD-1) gene rs36084323 A>G polymorphism has been investigated for its association with cancer risk.
  • Previous studies yielded inconsistent results, necessitating a comprehensive meta-analysis.

Purpose of the Study:

  • To evaluate the association between the PD-1 rs36084323 A>G polymorphism and cancer risk.
  • To clarify the conflicting findings from prior research through a meta-analysis.

Main Methods:

  • A systematic literature search was conducted across PubMed, EMBASE, Cochrane Library, CNKI, WANFANG, and CBM databases.
  • Data from 10 studies, including 4445 cancer cases and 5126 controls, were extracted and analyzed using odds ratios (ORs) and 95% confidence intervals (CIs).
  • Stratified analyses and meta-regression were employed to explore heterogeneity and subgroup associations.

Main Results:

  • Overall, the PD-1 rs36084323 A>G polymorphism showed no statistically significant association with overall cancer risk.
  • Stratified analysis revealed a statistically significant reduction in cancer risk among Asian individuals and patients with epithelial ovarian cancer (EOC).
  • Meta-regression identified ethnicity as a significant source of heterogeneity, while cancer type, control source, and sample size did not.

Conclusions:

  • The PD-1 rs36084323 A>G polymorphism is associated with decreased cancer risk in Asian populations.
  • This polymorphism may potentially serve as a biomarker for screening high-risk individuals.
  • Further large-scale, well-designed case-control studies are recommended to validate these findings.