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Electromagnetic Regulation of Cell Activity.
Sarah A Stanley1,2, Jeffrey M Friedman3,4
1Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Cold Spring Harbor Perspectives in Medicine
|September 26, 2018
Summary
Researchers developed a novel method using magnetic fields and nanoparticles to rapidly and noninvasively control cell activity. This technology offers precise temporal regulation for physiological studies and therapeutic applications in vitro and in vivo.
Area of Science:
- Biophysics
- Cell Biology
- Neuroscience
Background:
- Regulating cell activity is crucial for understanding physiology.
- Optical, chemical, and electromagnetic methods exist for cell control.
- Electromagnetic fields offer noninvasive tissue penetration.
Purpose of the Study:
- To explore electromagnetic fields for cell activity regulation.
- To investigate genetically encoded nanoparticles for targeted cell control.
- To enable rapid, noninvasive modulation of cellular functions.
Main Methods:
- Utilizing electromagnetic fields to interact with nanoparticles (external or genetically encoded).
- Employing nanoparticles, including ferritin, to absorb and release energy.
- Applying magnetic fields to gate endogenous or engineered receptors and ion channels.
Main Results:
- Demonstrated targeted, temporal control of cell activity in vitro and in vivo.
- Showcased noninvasive modulation of gene expression and intracellular organelles.
- Achieved whole-cell activity control in freely moving animals.
Conclusions:
- Electromagnetic fields interacting with nanoparticles provide a rapid, noninvasive method for cell activity regulation.
- Genetically encoded nanoparticles offer advanced control over cellular processes.
- This technology advances physiological research and potential therapeutic interventions.
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