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From mechanobiology to developmentally inspired engineering.

Donald E Ingber1,2,3,4

  • 1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA don.ingber@wyss.harvard.edu.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|September 26, 2018
PubMed
Summary
This summary is machine-generated.

Mechanobiology, the study of physical forces in biology, has advanced significantly over 40 years. Researchers are now using mechanoregulation principles for new tools, organ engineering, and therapies.

Keywords:
mechanicalorgans-on-chipstensegritytissue engineering

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Area of Science:

  • Mechanobiology
  • Developmental Biology
  • Physiology

Background:

  • Mechanobiology recognizes the critical role of physical forces in biological development and function.
  • The field has grown significantly over the past four decades.

Purpose of the Study:

  • To review 40 years of research that contributed to the emergence of mechanobiology.
  • To discuss the application of mechanoregulation principles in developing new experimental tools and organ-engineering strategies.
  • To highlight the development of novel mechanotherapeutics.

Main Methods:

  • Review of historical research in mechanobiology.
  • Application of mechanoregulation principles.
  • Development of experimental tools and organ-engineering approaches.
  • Creation of novel mechanotherapeutics.

Main Results:

  • Established the foundational principles of mechanobiology.
  • Demonstrated the utility of mechanoregulation in creating innovative biological tools and therapies.
  • Paved the way for advancements in organ engineering.

Conclusions:

  • Mechanobiology is a vital field with significant implications for development and physiology.
  • The principles of mechanoregulation offer a powerful framework for therapeutic and engineering innovations.
  • Continued research in mechanobiology promises further breakthroughs in medicine and biotechnology.