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Embryo movements regulate tendon mechanical property development.

Xuan Sabrina Pan1,2, Jiewen Li1,2, Edward B Brown1,3,4

  • 1Department of Biomedical Engineering, University of Rochester, Rochester, NY 14620, USA.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|September 26, 2018
PubMed
Summary
This summary is machine-generated.

Embryo movements are crucial for developing functional tendons. This study shows altered movement affects tendon stiffness and implicates lysyl oxidase (LOX) in this load-dependent process.

Keywords:
biomechanicscross-linksembryolysyl oxidasemechanical propertiestendon

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Area of Science:

  • Developmental biology
  • Biomechanics
  • Tendon research

Background:

  • Tendons transmit forces for skeletal movement.
  • Embryonic movements initiate load-bearing in developing tendons.
  • Tendon mechanical properties are essential for function.

Purpose of the Study:

  • To investigate the impact of embryonic movement on calcaneal tendon mechanical properties.
  • To determine the role of lysyl oxidase (LOX) in load-induced tendon development.

Main Methods:

  • Utilized the chick embryo model to study tendon development.
  • Manipulated embryonic movement frequency (paralysis and hypermotility).
  • Assessed calcaneal tendon elastic modulus and lysyl oxidase (LOX) activity.

Main Results:

  • Altered embryonic movement frequency changed tendon elastic modulus.
  • Paralysis decreased modulus; hypermotility increased modulus.
  • Lysyl oxidase (LOX) activity was reduced in paralyzed embryos and inhibition abrogated hypermotility-induced modulus increase.

Conclusions:

  • Embryonic movements are critical for developing tendon mechanical properties.
  • Lysyl oxidase (LOX) plays a key role in mediating the effects of mechanical loading on tendon development.
  • Findings inform understanding of tendon defects related to in utero mechanical loading.