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Quantifying blood flow dynamics during cardiac development: demystifying computational methods

Katherine Courchaine1, Sandra Rugonyi2

  • 1Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|September 26, 2018
PubMed

Insights

Blood flow (haemodynamics) is vital for cardiovascular development, influencing growth and preventing congenital heart defects. New technologies and 3D modeling help quantify these forces, revealing crucial mechanisms in heart formation.

Area of Science:

  • Cardiovascular Development
  • Biomedical Engineering
  • Developmental Biology

Background:

  • Hemodynamics significantly impact embryonic cardiovascular growth and development.
  • Altered blood flow is linked to congenital heart disease and malformations.
  • Mechanisms linking blood flow mechanics to cardiovascular development are not fully understood.

Purpose of the Study:

  • To summarize fundamental aspects of blood flow dynamics modeling.
  • To focus on 3D modeling techniques for cardiovascular development.
  • To discuss studies revealing blood flow's influence on heart and vascular formation.

Main Methods:

  • Utilizing recent technologies for precise measurement of blood flow parameters and cardiovascular geometry.
  • Applying computational fluid dynamics (CFD) techniques.
  • Focusing on three-dimensional (3D) modeling approaches.

Main Results:

  • Quantification of hemodynamic parameters and their developmental changes is now possible.
  • 3D modeling and advanced measurement technologies enable detailed analysis.
  • Studies are revealing specific mechanisms of blood flow influence.

Conclusions:

  • Understanding blood flow dynamics is critical for deciphering cardiovascular development.
  • Advanced modeling and measurement techniques are key to uncovering these mechanisms.
  • This research contributes to understanding mechanical cues in heart and vascular formation.

Keywords:
blood flow dynamicscardiovascular developmentcomputational fluid dynamicshaemodynamicsmechanotransduction

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