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A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
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Diabetes mellitus might be a protective factor of glioma

Ting-Ting Ni1

  • 1Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China.

Journal of Cancer Research and Therapeutics
|September 26, 2018
PubMed
Abstract

Insights

This meta-analysis indicates diabetes mellitus (DM) may reduce glioma risk. The association was significant in younger populations and males, but not in older populations or females.

Area of Science:

  • Neuro-oncology
  • Endocrinology
  • Epidemiology

Background:

  • Conflicting evidence exists regarding the association between diabetes mellitus (DM) and glioma risk.
  • Previous studies have yielded inconsistent results, necessitating further investigation.

Purpose of the Study:

  • To conduct a meta-analysis to clarify the relationship between DM and glioma risk.
  • To synthesize findings from existing studies to provide a more definitive conclusion.

Main Methods:

  • A systematic literature search was performed across PubMed, Embase, and Web of Science databases.
  • Keywords used included "glioma" and "diabetes" or "DM".
  • The association was quantified using odds ratios (ORs) with 95% confidence intervals (95% CIs).

Main Results:

  • Ten studies were included in the final meta-analysis.
  • A statistically significant association was found between DM and a reduced risk of glioma (OR = 0.84; 95% CI, 0.73-0.97; P = 0.02).
  • Subgroup analyses revealed a decreased glioma risk in younger populations (OR = 0.83; 95% CI, 0.70-0.98; P = 0.02) and males (OR = 0.82; 95% CI, 0.68-0.99; P = 0.04) with DM, but no significant association in older populations or females.

Conclusions:

  • The meta-analysis suggests that diabetes mellitus may be associated with a reduced risk of glioma.
  • This protective association appears more pronounced in younger individuals and males.
Keywords:
Associationdiabetes mellitusgliomameta-analysis

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