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Predictive Immune Modeling of Solid Tumors
Published on: February 25, 2020
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Hepatitis B and C rates are significantly increased in certain solid tumors: A large retrospective study
Hakan Kocoglu1, Mustafa Karaca2, Deniz Tural3
1Department of Internal Medicine, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
Journal of Cancer Research and Therapeutics
|September 26, 2018
Summary
Hepatitis B (HBV) and C (HCV) virus prevalence was studied in cancer patients. Certain solid tumors showed significantly higher HBV and HCV rates compared to controls, suggesting a link.
Area of Science:
- Hepatology and Oncology
- Viral Hepatitis Epidemiology
- Cancer Patient Health
Background:
- Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections pose significant risks for cancer patients undergoing chemotherapy.
- Understanding the prevalence of HBV and HCV in cancer populations is crucial for patient management and outcomes.
- Cytotoxic chemotherapy can exacerbate the impact of viral hepatitis in cancer patients.
Purpose of the Study:
- To determine the prevalence of HBV and HCV infections in a large cohort of patients with solid tumors and lymphoma.
- To compare HBV and HCV positivity rates between cancer patients and a large control group.
- To identify specific cancer types with potentially elevated rates of HBV and HCV.
Main Methods:
- Retrospective analysis of 3890 cancer patients admitted to Oncology Departments between 2000 and 2014.
- Comparison of hepatitis serology results (HBsAg for HBV, anti-HCV for HCV) with a control group of 96,000 subjects.
- Statistical analysis to compare positivity rates between cancer patients and controls, and among different cancer types.
Main Results:
- Overall HBV and HCV positivity rates were not significantly different between cancer patients (3.65% HBsAg, 1.2% anti-HCV) and controls (3.3% HBsAg, 0.84% anti-HCV).
- Significantly higher HBsAg positivity rates were observed in patients with head and neck (5.88%), rectum (5.6%), and gastric/esophageal cancers (5.88%) compared to controls.
- A significantly higher anti-HCV positivity rate (2.5%) was found in lung cancer patients compared to the control group.
Conclusions:
- While overall HBV and HCV prevalence did not differ significantly in the total cancer cohort, specific solid tumors show elevated rates.
- Head and neck, rectal, gastric, esophageal, and lung cancers are associated with increased prevalence of HBV and/or HCV.
- Further large-scale prospective studies are warranted to confirm these findings and explore clinical implications.
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