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Galectin-3 Interacts with Vascular Cell Adhesion Molecule-1 to Increase Cardiovascular Mortality in Hemodialysis

Wen-Chin Ko1,2, Cheuk-Sing Choy3,4,5, Wei-Ning Lin6

  • 1College of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan. 086938@mail.fju.edu.tw.

Journal of Clinical Medicine
|September 26, 2018
PubMed

Insights

In maintenance hemodialysis patients, high levels of galectin-3 and vascular cell adhesion molecule 1 (VCAM-1) significantly increase risks for all-cause and cardiovascular mortality. These biomarkers show a combined effect, highlighting their prognostic value.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Biomarker Research

Background:

  • The combined impact of galectin-3 and vascular cell adhesion molecule 1 (VCAM-1) on mortality in maintenance hemodialysis (MHD) patients is not well understood.
  • Understanding these interactions is crucial for improving prognostic assessments in this high-risk population.

Purpose of the Study:

  • To investigate the independent and joint effects of serum galectin-3 and VCAM-1 on all-cause and cardiovascular (CV) mortality risks in MHD patients.
  • To determine if galectin-3 and VCAM-1 can serve as dual biomarkers for predicting mortality.

Main Methods:

  • Analysis of unadjusted and adjusted hazard ratios (aHRs) for mortality in patients categorized by higher and lower serum concentrations of galectin-3 and VCAM-1.
  • Investigation of the modification effect between galectin-3 and VCAM-1 on mortality risk using an interaction product term.

Main Results:

  • Both galectin-3 and VCAM-1 were independently associated with increased all-cause mortality risk.
  • VCAM-1, but not galectin-3, showed a trend towards predicting cardiovascular mortality.
  • Patients with combined high levels of galectin-3 and VCAM-1 exhibited the greatest risk for both all-cause and CV mortality, with statistically significant interactions observed (p < 0.01 for all-cause, p < 0.05 for CV).

Conclusions:

  • Galectin-3 and VCAM-1 demonstrate significant joint effects on mortality risk in MHD patients.
  • These biomarkers hold promise as a dual prognostic tool, potentially related to their roles in leukocyte trafficking and atherothrombosis.
Abstract

Keywords:
cell adhesion moleculesgalectinhemodialysismortality

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