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Published on: February 3, 2017
Autophagy in Metabolic Age-Related Human Diseases
1INSERM, UMR-1048, Institute of Cardiovascular and Metabolic Diseases and University Paul Sabatier; F-31342 Toulouse, France. manon.moulis@inserm.fr.
Abstract:
Autophagy is a highly conserved homeostatic cellular mechanism that mediates the degradation of damaged organelles, protein aggregates, and invading pathogens through a lysosome-dependent pathway. Over the last few years, specific functions of autophagy have been discovered in many tissues and organs; however, abnormal upregulation or downregulation of autophagy has been depicted as an attribute of a variety of pathologic conditions. In this review, we will describe the current knowledge on the role of autophagy, from its regulation to its physiological influence, in metabolic age-related disorders. Finally, we propose to discuss the therapeutic potential of pharmacological and nutritional modulators of autophagy to treat metabolic diseases.
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