Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Poliomyelitis immunity status at different intervals from vaccination.

E Bellelli, U Bracchi, M L Tanzi

    European Journal of Epidemiology
    |September 1, 1986
    PubMed
    Summary

    This study found that while most children develop poliovirus antibodies after two or more oral poliovirus vaccine (OPV) doses, immunity wanes over time for types 2 and 3. Consistent high immunity levels were not observed across all regions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Safety and tolerability of Meningococcus B vaccine in patients with chronical medical conditions (CMC).

    Italian journal of pediatrics·2019
    Same author

    Sporadic isolation of sabin-like polioviruses and high-level detection of non-polio enteroviruses during sewage surveillance in seven Italian cities, after several years of inactivated poliovirus vaccination.

    Applied and environmental microbiology·2014
    Same author

    Immunity status against poliomyelitis in childbearing women in a province of northern Italy -- reply.

    Annali di igiene : medicina preventiva e di comunita·2014
    Same author

    Immunity status against poliomyelitis in childbearing women in a province of northern Italy. A cross-sectional analysis.

    Annali di igiene : medicina preventiva e di comunita·2013
    Same author

    Pregnancy in a methylmalonic acidemia patient with kidney transplantation: a case report.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2013
    Same author

    Comparison of times of intervention during pediatric CPR maneuvers using ABC and CAB sequences: a randomized trial.

    Resuscitation·2012

    Area of Science:

    • Immunology
    • Virology
    • Public Health

    Background:

    • Polio remains a significant public health concern, necessitating robust vaccination strategies.
    • Understanding antibody persistence after oral poliovirus vaccine (OPV) is crucial for assessing population immunity.

    Purpose of the Study:

    • To evaluate neutralizing antibody levels against poliovirus serotypes in a vaccinated population.
    • To assess the impact of OPV dosage and time since vaccination on antibody persistence.

    Main Methods:

    • Analysis of 441 blood samples from children and young people in Parma, Italy, at various vaccination stages.
    • Measurement of neutralizing antibodies against poliovirus types 1, 2, and 3.
    • Comparison of antibody geometric mean titers (GMTs) based on vaccination status and time elapsed since vaccination.

    Related Experiment Videos

    Main Results:

    • Unvaccinated infants showed antibody deficiencies for poliovirus types 1 and 3. A single OPV dose left 5% without type 1 antibodies.
    • Two or more OPV doses conferred antibodies against all three poliovirus serotypes.
    • Antibody GMTs for type 1 differed significantly with dose number. Immunity persisted for 2-14 years post-vaccination, though types 2 and 3 showed decreases between 2-5 years.

    Conclusions:

    • Trivalent OPV vaccination effectively induces poliovirus antibodies, with higher doses correlating with better type 1 antibody levels.
    • While immunity is generally long-lasting, waning antibody levels for poliovirus types 2 and 3 warrant monitoring.
    • Observed immunity levels in Parma were not uniformly high across the entire region, suggesting potential geographical disparities in vaccine effectiveness or coverage.