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Updated: Feb 4, 2026

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
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In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

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Cerebral Malaria in Mouse and Man

Nazanin Ghazanfari1,2, Scott N Mueller1,2, William R Heath1,2

  • 1Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.

Frontiers in Immunology
|September 26, 2018
PubMed

Insights

Cerebral malaria (CM), a severe complication of Plasmodium falciparum infection, has poorly understood pathogenic mechanisms. Recent studies in mouse models and humans offer new insights into CM pathogenesis for developing novel therapies.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Immunology

Background:

  • Cerebral malaria (CM) is a severe neurological complication caused by Plasmodium falciparum infection.
  • CM is a leading cause of death in African children, yet its pathogenesis remains poorly understood.
  • Decades of research have yet to fully elucidate the mechanisms driving CM.

Purpose of the Study:

  • To review recent findings on the pathogenesis of cerebral malaria.
  • To synthesize insights from both animal models and human studies.
  • To identify potential avenues for novel therapeutic development.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of data from mouse models of CM.
  • Examination of findings from human patient studies.

Main Results:

  • Recent research has significantly advanced the understanding of CM pathogenesis.
  • Studies highlight the complex interplay of factors contributing to CM.
  • Insights gained from diverse research approaches are converging.

Conclusions:

  • A clearer understanding of CM pathogenesis is emerging from combined research efforts.
  • This enhanced knowledge may pave the way for developing new treatments for cerebral malaria.
  • Further research integrating animal models and human data is crucial for combating CM.
Keywords:
Plasmodium bergheiPlasmodium falciparumT cellsblood-brain barriercerebral malaria

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