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Related Concept Videos

Cerebral Hemispheres01:05

Cerebral Hemispheres

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The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
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In-vitro Mutagenesis01:16

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To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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Related Experiment Video

Updated: Feb 4, 2026

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
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Cerebral Malaria in Mouse and Man.

Nazanin Ghazanfari1,2, Scott N Mueller1,2, William R Heath1,2

  • 1Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.

Frontiers in Immunology
|September 26, 2018
PubMed
Summary

Cerebral malaria (CM), a severe complication of Plasmodium falciparum infection, has poorly understood pathogenic mechanisms. Recent studies in mouse models and humans offer new insights into CM pathogenesis for developing novel therapies.

Keywords:
Plasmodium bergheiPlasmodium falciparumT cellsblood-brain barriercerebral malaria

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Immunology

Background:

  • Cerebral malaria (CM) is a severe neurological complication caused by Plasmodium falciparum infection.
  • CM is a leading cause of death in African children, yet its pathogenesis remains poorly understood.
  • Decades of research have yet to fully elucidate the mechanisms driving CM.

Purpose of the Study:

  • To review recent findings on the pathogenesis of cerebral malaria.
  • To synthesize insights from both animal models and human studies.
  • To identify potential avenues for novel therapeutic development.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of data from mouse models of CM.
  • Examination of findings from human patient studies.

Main Results:

  • Recent research has significantly advanced the understanding of CM pathogenesis.
  • Studies highlight the complex interplay of factors contributing to CM.
  • Insights gained from diverse research approaches are converging.

Conclusions:

  • A clearer understanding of CM pathogenesis is emerging from combined research efforts.
  • This enhanced knowledge may pave the way for developing new treatments for cerebral malaria.
  • Further research integrating animal models and human data is crucial for combating CM.