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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
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The Nursing Code of Ethics sets the ethical benchmark for the profession, and guides nurses in ethical analysis and decision making at the societal, organizational, and clinical levels. The code encompasses showing compassion and respect for the patient, their families, and communities in all circumstances while committing to providing patient-centered care. In addition, the code states that nurses must advocate for the patient by defending a cause or recommendation to protect their rights,...
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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Editorial focus: entering into the non-coding RNA era.

Rafal Bartoszewski1, Aleksander F Sikorski2

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New classes of non-coding RNAs (ncRNAs) are emerging, regulating gene expression and genome remodeling. Understanding these crucial molecules is vital for cell biology and disease research.

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Area of Science:

  • Molecular Biology
  • Genomics
  • Cell Biology

Background:

  • High-throughput genotyping technologies have identified novel RNA classes.
  • These molecules, known as non-coding RNAs (ncRNAs), do not produce proteins.
  • ncRNAs play significant roles in regulating cellular functions.

Purpose of the Study:

  • To discuss the broader importance of non-coding RNA research.
  • To highlight the growing interest in ncRNAs within the scientific community.

Main Methods:

  • Review of recent developments in high-throughput genotyping.
  • Analysis of the known functions of non-coding RNAs in gene expression and genome remodeling.

Main Results:

  • Identification of multiple new classes of ncRNAs.
  • Demonstration of ncRNAs' roles in modulating gene expression.
  • Evidence of ncRNAs' involvement in genome remodeling processes.

Conclusions:

  • Non-coding RNAs are critical regulators of cellular processes.
  • Further research into ncRNAs is essential for understanding normal and disease-related cellular functions.
  • The study of ncRNAs is a rapidly expanding field in molecular biology.