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Updated: Feb 4, 2026

Photostimulation by Femtosecond Laser Activates Extracellular-signal-regulated Kinase ERK Signaling or Mitochondrial Events in Target Cells
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Photostimulation by Femtosecond Laser Activates Extracellular-signal-regulated Kinase ERK Signaling or Mitochondrial Events in Target Cells

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Targeting kinases with precision

Alexandra K Gardino1, Erica K Evans1, Joseph L Kim1

  • 1Blueprint Medicines, Cambridge, MA, USA.

Molecular & Cellular Oncology
|September 26, 2018
PubMed

Insights

Cancer genomics reveals diverse kinase mutations, posing challenges for drug discovery. Tailored strategies are needed to develop precise cancer therapies based on tumor molecular profiles.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Cancer genomics has identified heterogeneous mutations in kinases, leading to varied activation mechanisms.
  • Developing potent and selective drugs against these mutated kinases presents a significant challenge.

Purpose of the Study:

  • To bridge the gap between cancer genomic insights and drug discovery strategies.
  • To enable the development of precision cancer medicines tailored to individual tumor genotypes.

Main Methods:

  • Analysis of cancer genomics data.
  • Mechanistic studies of kinase activation.
  • Drug discovery and optimization strategies.

Main Results:

  • Identification of diverse kinase activation mechanisms driven by heterogeneous mutations.
  • Development of strategies for creating potent and selective kinase inhibitors.

Conclusions:

  • Optimized drugs can facilitate personalized medicine approaches.
  • Precision treatment based on molecular tumor genotype is achievable with advanced therapeutic options.
Keywords:
BLU-285avapritinibgastrointestinal stromal tumorprecision medicinesystemic mastocytosis

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