Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lift01:23

Lift

539
Lift is a fundamental aerodynamic force that acts perpendicular to the direction of airflow. It plays a central role in achieving and sustaining flight and in stabilizing various vehicles. Lift primarily originates from pressure differences created across surfaces, such as an airfoil. A lower pressure region forms above the wing, while a higher pressure region forms below it, generating an upward force. This differential results from the shape and orientation of the airfoil, enabling the wing...
539
Repressed Memory01:16

Repressed Memory

519
Repressed memories are a psychological phenomenon where memories of traumatic events are unconsciously blocked from a person's awareness. This process occurs as a defense mechanism, protecting the mind from the emotional impact of distressing or painful experiences. For example, a person who has experienced childhood trauma may grow up with no conscious recollection of the event. In such cases, the memories are thought to be buried deep within the subconscious, inaccessible to the conscious...
519
Nursing Implementation01:15

Nursing Implementation

6.2K
Implementation is the execution of the nursing care plan developed during the planning phase.
The five steps to implementing effective nursing care include reassessing the patient, reviewing and revising the existing nursing care plan, organizing the resources and care delivery, anticipating and preventing complications, and implementing nursing interventions.
6.2K
Repressible Operon: trp Operon01:21

Repressible Operon: trp Operon

1.6K
The trp operon in Escherichia coli exemplifies a repressible operon. It regulates the synthesis of tryptophan through repressor-mediated transcriptional control and attenuation. This dual regulatory mechanism ensures tryptophan biosynthesis occurs only when needed, conserving cellular resources.Structure of the trp OperonThe trp operon consists of five structural genes (trpE, trpD, trpC, trpB, and trpA) that encode enzymes for tryptophan biosynthesis. These genes are transcribed as a single...
1.6K
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

24.9K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
24.9K
Gene Flow02:39

Gene Flow

37.9K
Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
37.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metal-Free Ternary-Composite Aerogel Based on Graphitic Carbon Nitride, Graphene Oxide, and β-Cyclodextrin for Synergistic Adsorption and Photodegradation of Organic Dyes.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Fractionated high-dose vitamin c sustains higher plasma trough concentrations in advanced solid tumors: a phase I clinical study.

Translational oncology·2026
Same author

Assessing the impact of polycyclic aromatic hydrocarbon exposure on liver cancer using network toxicology and molecular docking.

Molecular diversity·2026
Same author

DNA hydrogel-delivered hypoxic exosomes alleviate radiation-induced skin injury by stabilizing AKT.

Journal of nanobiotechnology·2026
Same author

ATG Plus Post-Transplantation Cyclophosphamide Improves EBV-DNA Clearance and GVHD in Patients of Adult Chronic Active Epstein-Barr Virus Disease Undergoing Allogeneic HSCT.

Journal of blood medicine·2026
Same author

Interpretable machine learning to predict NOAF in ICU patients with CKD: validation in US and Chinese cohorts.

Frontiers in medicine·2026

Related Experiment Video

Updated: Feb 4, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

6.9K

AMPK lifts the PRC2-implemented gene repression.

Tao Han1, Qing Yin1, Lixin Wan1,2

  • 1Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

Molecular & Cellular Oncology
|September 26, 2018
PubMed
Summary

Energy restriction activates AMPK, which phosphorylates EZH2. This disrupts PRC2 complex integrity, inhibiting its cancer-promoting functions in ovarian and breast cells.

Keywords:
AMPKEZH2PRC2energy restriction

More Related Videos

Methanol Independent Expression by Pichia Pastoris Employing De-repression Technologies
05:30

Methanol Independent Expression by Pichia Pastoris Employing De-repression Technologies

Published on: January 23, 2019

14.5K
The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
06:05

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

1.8K

Related Experiment Videos

Last Updated: Feb 4, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

6.9K
Methanol Independent Expression by Pichia Pastoris Employing De-repression Technologies
05:30

Methanol Independent Expression by Pichia Pastoris Employing De-repression Technologies

Published on: January 23, 2019

14.5K
The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
06:05

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

1.8K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cancer Research

Background:

  • The interplay between cellular energy levels and epigenetic regulation is not well understood.
  • Epigenetic modifications play a crucial role in cancer development and progression.

Purpose of the Study:

  • To investigate the molecular mechanisms linking cellular energy status to epigenetic modifications.
  • To explore the role of AMP-activated protein kinase (AMPK) in regulating epigenetic modifiers.

Main Methods:

  • Utilized cell culture models of ovarian and breast cancer cells.
  • Applied biochemical assays to study protein-protein interactions and modifications.
  • Investigated the impact of energy restriction on the polycomb repressive complex 2 (PRC2) and its components.

Main Results:

  • Demonstrated that energy restriction leads to AMPK-mediated phosphorylation of enhancer of zeste homolog 2 (EZH2).
  • Showed that this phosphorylation event disrupts the structural integrity of the PRC2 complex.
  • Confirmed that the disruption of PRC2 integrity by phosphorylated EZH2 inhibits its oncogenic functions in cancer cells.

Conclusions:

  • Cellular energy status, through AMPK signaling, directly impacts epigenetic machinery like PRC2.
  • Targeting the AMPK-EZH2-PRC2 axis could offer novel therapeutic strategies for ovarian and breast cancers.