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Updated: Feb 4, 2026

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood
Published on: September 14, 2017
A Case of mistaken identity: Rhabdomyosarcoma development from endothelial progenitor cells
Catherine J Drummond1, Mark E Hatley1
1Department of Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, USA.
Abstract:
Rhabdomyosarcoma (RMS) histologically resembles developing skeletal muscle and is thought to solely originate from a differentiation block in muscle progenitors. We demonstrate that RMS can arise from endothelial progenitor cells following reprogramming and myogenic transdifferentiation. These results highlight how tumors with identical morphological features can arise from different cell types and offer insight into RMS formation in non-myogenic tissue.
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