Desacylghrelin but not acylghrelin is reduced during smoking cessation
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Updated: Feb 4, 2026

A Protocol for Detecting and Scavenging Gas-phase Free Radicals in Mainstream Cigarette Smoke
Published on: January 2, 2012
Mahsa Ardeshiripur1, Mathias Rhein1, Helge Frieling1
1Department of Psychiatry, Socialpsychiatry and Psychotherapy, Center for Addiction Research (CARe), Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Abstract:
This study focused on the acetylation status of ghrelin examining acyl- and desacylghrelin and its effect on craving during 14 days of smoking abstinence. This is the first study demonstrating changes in desacylghrelin plasma levels in smokers compared to non-smokers while there was no difference of acylated ghrelin. Future studies should specifically refer to plasma ghrelin as either desacyl- or acylghrelin since both have different effects on tobacco-seeking behavior and the underlying physiology.
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