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[Kingella kingae as a common cause of arthritis septic in children]

M Illán-Ramos1, S Guillén-Martín, L M Prieto-Tato

  • 1Marta Illán Ramos, Hospital Clínico San Carlos, C/Profesor Martín Lagos sn. CP: 28040, Madrid. Servicio de Pediatría (planta 6ª sur). Spain. marta_illan_ramos@hotmail.com.

Revista Espanola De Quimioterapia : Publicacion Oficial De La Sociedad Espanola De Quimioterapia
|September 26, 2018
PubMed

Insights

Kingella kingae causes invasive osteoarticular infections in young children, often underdiagnosed due to culture difficulties. PCR testing significantly improves diagnosis and management of these childhood infections.

Area of Science:

  • Pediatric Infectious Diseases
  • Microbiology
  • Rheumatology

Background:

  • Kingella kingae is a common oropharyngeal colonizer in children.
  • It is increasingly recognized as a cause of invasive osteoarticular infections in young children (<2 years old).
  • Underdiagnosis is common due to challenges in routine culture and lack of molecular diagnostics.

Purpose of the Study:

  • To describe the epidemiological and clinical characteristics of osteoarticular infections caused by K. kingae in children.
  • To highlight the role of K. kingae in childhood osteoarticular infections.
  • To report recent experience with K. kingae infections in Spain.

Main Methods:

  • Retrospective analysis of septic arthritis cases caused by K. kingae.
  • Identification of K. kingae using Polymerase Chain Reaction (PCR) in joint fluid.
  • Analysis of epidemiological, clinical, and laboratory data from affected children.

Main Results:

  • Five cases of K. kingae septic arthritis were identified in children aged ≤6 years.
  • Median leukocyte count was 12,950/μL, CRP 4.84 mg/dL, and ESR 58 mm/h.
  • Joint fluid analysis showed 61,322 leukocytes/μL; all patients had favorable outcomes.

Conclusions:

  • K. kingae osteoarticular infections in children often show mild increases in inflammatory markers.
  • PCR in sterile samples has significantly improved the diagnostic yield for K. kingae.
  • Improved diagnostics enhance the management of pediatric osteoarticular infections.
Abstract

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