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Updated: Feb 4, 2026

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Decarboxylative Negishi Coupling of Redox-Active Aliphatic Esters by Cobalt Catalysis
Xu-Ge Liu1, Chu-Jun Zhou1, E Lin1
1School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Abstract:
A cobalt-catalyzed decarboxylative Negishi coupling reaction of redox-active aliphatic esters with organozinc reagents was developed. The method enabled efficient alkyl-aryl, alkyl-alkenyl, and alkyl-alkynyl coupling reactions under mild reaction conditions with no external ligand or additive needed. The success of an in situ activation protocol and the facile synthesis of the drug molecule (±)-preclamol highlight the synthetic potential of this method. Mechanistic studies indicated that a radical mechanism is involved.
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