Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Global Climate Change01:50

Global Climate Change

28.9K
Throughout its ~4.5 billion year history, the Earth has experienced periods of warming and cooling. However, the current drastic increase in global temperatures is well outside of the Earth’s cyclic norms, and evidence for human-caused global climate change is compelling. Paleoclimatology, the study of ancient climate conditions, provides ample evidence for human-caused global climate change by comparing recent conditions with those in the past.
28.9K
Timing and Consequences on Behavior01:08

Timing and Consequences on Behavior

397
In operant conditioning, the timing of reinforcement is crucial. For animals like rats and cats, immediate reinforcement (within a few seconds) is much more effective than delayed reinforcement. For example, a food reward for a rat needs to follow within 30 seconds of pressing a bar to be effective. 
Humans, however, can respond to delayed reinforcers. We often make decisions between immediate small rewards and delayed larger rewards. This ability to delay gratification is a significant...
397
Molecular Shape and Polarity03:37

Molecular Shape and Polarity

75.8K
Dipole Moment of a Molecule
75.8K
VSEPR Theory and the Basic Shapes02:52

VSEPR Theory and the Basic Shapes

85.1K
Overview of VSEPR Theory
85.1K
Molecular Shapes01:18

Molecular Shapes

62.2K
Molecules have characteristic shapes that are crucial for their function. The arrangement of various electron groups around the central atom dictates their molecular geometry. Electron pairs in the valence shell of a central atom will adopt an arrangement that minimizes repulsions between the electron pairs by maximizing the distance between them. The valence electrons form either bonding pairs, located primarily between bonded atoms, or lone pairs.
Two regions of electron density in a diatomic...
62.2K
Rates of Change01:20

Rates of Change

119
The rate of change is a central concept in mathematics that quantifies how one variable varies in response to another. It serves as a foundational tool in modeling dynamic systems across disciplines such as physics, biology, economics, and engineering. Understanding both average and instantaneous rates of change enables the analysis of behavior in functions that describe real-world phenomena.Average Rate of ChangeFor a function f(x) defined over an interval [x1,x2], the average rate of change...
119

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Platelets as Programmable Drug Depots: Toward Predictive and Mechanistic Drug Loading.

Molecular pharmaceutics·2026
Same author

Reducing the Formation of Toxic Byproducts During the Photochemical Release of Epinephrine.

Journal of xenobiotics·2025
Same author

Prototype of Implant for Nitric Oxide Release Controlled by Infrared Radiation in Therapeutic Window.

Journal of biophotonics·2024
Same author

Adrenochrome formation during photochemical decomposition of "caged" epinephrine derivatives.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2024
Same author

Platelet activation near point-like source of agonist: Experimental insights and computational model.

PloS one·2024
Same author

Nitric Oxide Photorelease from Silicone Films Doped with N-Nitroso BODIPY.

Journal of functional biomaterials·2024

Related Experiment Video

Updated: Feb 4, 2026

Imaging Cell Shape Change in Living Drosophila Embryos
11:20

Imaging Cell Shape Change in Living Drosophila Embryos

Published on: March 30, 2011

14.8K

The platelet shape change: biophysical basis and physiological consequences.

Alexander E Moskalensky1,2, Alena L Litvinenko1,2

  • 1a Laboratory of Optics and Dynamics of Biological Systems , Novosibirsk State University , Novosibirsk , Russia.

Platelets
|September 26, 2018
PubMed
Summary
This summary is machine-generated.

Platelet shape change, a key activation marker, is driven by cytoskeletal biophysics. Microtubule rings balance tension in resting platelets, enabling rapid shape shifts during activation for improved adhesion.

Keywords:
Blood plateletscell shapecytoskeletonmicrotubulesplatelet activation

More Related Videos

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

1.2K
Purification of Platelets from Mouse Blood
05:41

Purification of Platelets from Mouse Blood

Published on: May 7, 2019

23.7K

Related Experiment Videos

Last Updated: Feb 4, 2026

Imaging Cell Shape Change in Living Drosophila Embryos
11:20

Imaging Cell Shape Change in Living Drosophila Embryos

Published on: March 30, 2011

14.8K
Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

1.2K
Purification of Platelets from Mouse Blood
05:41

Purification of Platelets from Mouse Blood

Published on: May 7, 2019

23.7K

Area of Science:

  • Biophysics
  • Cell Biology
  • Computational Biology

Background:

  • Platelet shape change is a universal indicator of platelet activation.
  • Understanding the biophysical mechanisms driving this transformation is crucial.

Purpose of the Study:

  • To review the biophysics of platelet shape change.
  • To explore the interplay of cytoskeletal subsystems in platelet mechanics.
  • To hypothesize the functional implications of shape transformation.

Main Methods:

  • Review of existing literature.
  • Analysis of physical principles governing cytoskeletal interactions.
  • Integration of mathematical and computational biology findings.

Main Results:

  • Resting platelets feature a microtubule ring counterbalancing cortical tension, creating a "mechanically charged" state.
  • Platelet activation disrupts this balance, leading to rapid microtubule ring buckling and cell rounding.
  • The disk-to-sphere transformation is hypothesized to enhance platelet adhesion under flow conditions.

Conclusions:

  • Platelet shape change is a mechanically regulated process.
  • Cytoskeletal dynamics are central to platelet activation and function.
  • Findings may inform the development of novel antiplatelet therapies targeting the cytoskeleton.