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Related Experiment Video

Updated: Feb 4, 2026

Cargo Loading onto Kinesin Powered Molecular Shuttles

Cargo Loading onto Kinesin Powered Molecular Shuttles

Published on: November 3, 2010

Microalga-Powered Microswimmers toward Active Cargo Delivery.

Oncay Yasa¹, Pelin Erkoc¹, Yunus Alapan¹

¹Physical Intelligence Department, Max Planck Institute for Intelligent Systems, 70569, Stuttgart, Germany.

Advanced Materials (Deerfield Beach, Fla.)

|September 26, 2018

Summary

Researchers developed biocompatible biohybrid microswimmers using algae to deliver cargo. These microswimmers show promising motility and cytocompatibility for targeted drug delivery applications in medicine.

Keywords:

Chlamydomonas reinhardtii biohybrids cargo delivery microalgae microswimmers

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Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

Area of Science:

Biomedical Engineering
Microbiology
Materials Science

Background:

Biological swimmers possess natural energy harvesting capabilities.
Utilizing natural swimmers for cargo delivery offers an alternative to traditional methods for accessing difficult body locations.

Purpose of the Study:

To develop a biocompatible biohybrid microswimmer powered by the alga Chlamydomonas reinhardtii.
To investigate the motility and cargo delivery capabilities of these microswimmers in various physiological conditions.

Main Methods:

Engineered biohybrid microswimmers by attaching magnetic cargoes to Chlamydomonas reinhardtii via noncovalent interactions.
Characterized 3D swimming motility under magnetic fields and in different physiological fluids (cell culture medium, human tubal fluid, plasma, blood).
Assessed cytocompatibility with healthy and cancerous cells and demonstrated cargo delivery using fluorescent isothiocyanate-dextran.

Main Results:

Successfully constructed biohybrid algal microswimmers with controllable motility using magnetic fields.
Demonstrated microswimmer motility in diverse physiologically relevant conditions.
Confirmed cytocompatibility with both healthy and cancerous cells.
Achieved effective delivery of fluorescent molecules to mammalian cells, proving the cargo delivery potential.

Conclusions:

The developed biohybrid microswimmers offer a novel, biocompatible platform for targeted delivery.
Enhanced motility and biocompatibility make these microswimmers suitable for advanced medical applications.
This approach presents a new class of microswimmers for targeted therapeutic delivery.