Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evidence to Decision framework provides a structured "roadmap" for making GRADE guidelines recommendations.

Shelly-Anne Li1, Paul E Alexander2, Tea Reljic3

  • 1Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, 155 College Street, Toronto, Ontario M5T 1P8, Canada.

Journal of Clinical Epidemiology
|September 26, 2018
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ianalumab plus Eltrombopag in Immune Thrombocytopenia. Reply.

The New England journal of medicine·2026
Same author

ASH Clinical Practice Guidelines - Evaluation of discordance between certainty of evidence and strength of recommendations.

Blood advances·2026
Same author

Cost-effectiveness of iron deficiency screening in pregnancy across ferritin-based thresholds.

Blood advances·2026
Same author

How to monitor and manage unfractionated heparin in practice (Part 1)? Guidance from the SSC of the ISTH.

Journal of thrombosis and haemostasis : JTH·2026
Same author

2026 American Association for Thoracic Surgery Expert Consensus Document: Diagnosis and management of heparin-induced thrombocytopenia in patients who undergo cardiac surgery.

The Journal of thoracic and cardiovascular surgery·2026
Same author

Expert Opinion on Implementing Oral Anticoagulation Reversal Protocols in US Hospitals.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·2026

Guidelines panelists primarily used research evidence when applying the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) Evidence to Decision (EtD) framework. The GRADE EtD framework structured discussions and ensured consideration of formal criteria.

Area of Science:

  • Clinical practice guidelines development
  • Health technology assessment
  • Evidence-based medicine

Background:

  • The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach is widely used for guideline development.
  • The Evidence to Decision (EtD) framework is a component of GRADE used to structure decision-making.
  • It remains unclear how guideline panelists consider formal GRADE criteria and other factors during guideline development.

Purpose of the Study:

  • To explore how guideline panelists adhere to formal GRADE criteria.
  • To identify any non-GRADE criteria considered by panelists.
  • To describe the use of decision criteria within the GRADE EtD framework.

Main Methods:

  • Conventional and summative qualitative analyses were used.
Keywords:
Clinical practice guidelinesDecision-makingEpidemiologyEvidence to Decision frameworkGRADEgroup processing

Related Experiment Videos

  • Analysis of face-to-face panel meeting discussions.
  • Study involved 48 panelists from 12 countries developing guidelines for venous thromboembolism management.

    • Main Results:

    • Ten themes emerged, all corresponding to the GRADE approach.
    • Over half (53%) of panel discussions focused on research evidence.
    • Decision-making was rapid when evidence was clear and sufficient.

    Conclusions:

    • The GRADE EtD framework structures panel meetings and ensures consideration of formal GRADE criteria.
    • This is the first study to assess the GRADE EtD framework's use in real-time guideline development.
    • Understanding the use of GRADE and non-GRADE criteria enhances transparency in guideline development.