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Updated: Feb 4, 2026

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
Published on: August 21, 2019
Limits on reconstruction of dynamics in networks
Jiajing Guan1, Tyrus Berry1, Timothy Sauer1
1George Mason University, Fairfax, Virginia 22030, USA.
We introduce an observability condition number for network dynamics. This metric predicts if system trajectory reconstruction is feasible from limited noisy observations, guiding optimal sensor placement.
Area of Science:
- Network dynamics
- Systems theory
- Control theory
Background:
- Physical systems are often modeled using network dynamics.
- Observability is crucial for understanding and controlling these systems.
- Limited or noisy observations pose challenges for state reconstruction.
Purpose of the Study:
- To define and analyze an observability condition number for network dynamics.
- To assess the feasibility of trajectory reconstruction from partial, noisy observations.
- To guide the selection of optimal observation subsets for network monitoring.
Main Methods:
- Definition of an observability condition number based on network structure and dynamics.
- Calculation of the expected distance to the nearest correct trajectory under varying noise levels.
- Analysis of how this distance varies across unobserved nodes.
Main Results:
- The observability condition number quantifies the difficulty of trajectory reconstruction.
- Reconstruction becomes infeasible when the condition number is sufficiently large.
- The condition number's behavior highlights vulnerabilities in unobserved network parts.
Conclusions:
- The proposed condition number provides a quantitative measure for network observability.
- It enables informed decisions on sensor placement for effective system monitoring.
- Understanding observability limitations is key for reliable state estimation in complex networks.
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