Related Experiment Video

Updated: Feb 4, 2026

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
08:53

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma

Published on: June 10, 2017

10.5K

Nivolumab induces impressive responses in relapsed/refractory classic Hodgkin lymphoma: Single institutional

Reyad Dada1,2, Yazeed Zabani3

  • 11 King Faisal Specialist Hospital and Research Centre, Jeddah, Kingdom of Saudi Arabia.

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
|September 27, 2018
PubMed
Abstract

Insights

Nivolumab, a PD-1 inhibitor, shows high response rates and excellent tolerability in heavily pretreated classical Hodgkin lymphoma patients. This immunotherapy revives the immune system against cancer, offering a promising new treatment option.

Area of Science:

  • Immunology
  • Oncology
  • Pharmacology

Background:

  • Cancer immune evasion mechanisms include Program Death Ligand-1 (PD-L1) expression, which inhibits T-cell responses.
  • PD-1 receptor interaction with PD-L1 leads to immune tolerance, allowing cancer cells to escape immune surveillance.
  • Nivolumab is a novel antibody designed to block the PD-1 pathway, thereby preventing immune suppression.

Purpose of the Study:

  • To evaluate the efficacy and safety of nivolumab in heavily pretreated patients with classical Hodgkin lymphoma.
  • To assess the response rate and tolerability of PD-1 inhibition in this patient population.

Main Methods:

  • A cohort of 10 heavily pretreated classical Hodgkin lymphoma patients received nivolumab.
  • Treatment involved four cycles of the PD-1 inhibitor.
  • Patient outcomes and adverse events were closely monitored and reported.

Main Results:

  • An overall response rate of 80% was observed after four cycles of nivolumab.
  • Seven out of 10 patients achieved complete metabolic remission.
  • No serious adverse events were reported during the study, indicating good tolerability.

Conclusions:

  • Classical Hodgkin lymphoma, even in pretreated patients, is responsive to novel immunotherapy with nivolumab.
  • Nivolumab demonstrates clinically significant efficacy and excellent tolerability, expanding treatment options.
  • Further large-scale controlled studies are warranted to confirm these findings in a broader patient population.
Keywords:
Hodgkin lymphomaNivolumabprogram death ligand-1

More Related Videos

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence08:05

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

Published on: March 23, 2022

3.1K
Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia08:31

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Published on: October 17, 2025

697

Related Concept Videos

First Impression01:09

First Impression

First impressions play a crucial role in social perception, shaping how individuals assess others in professional, academic, and interpersonal contexts. Psychological research highlights the significance of cognitive biases, such as the primacy and recency effects, which influence how people interpret and recall information.The Primacy Effect and Cognitive AnchoringThe primacy effect describes the tendency for initial information to impact judgment disproportionately. When individuals encounter...
223
Classical Conditioning01:18

Classical Conditioning

Associative learning, a core principle in behavioral psychology, involves forming connections between events and facilitating learned responses. This concept is vividly illustrated by classical conditioning, a process extensively studied by the Russian physiologist Ivan Pavlov. Pavlov's pioneering research on dogs' digestive systems led to the discovery that behaviors can be learned through association, laying the groundwork for classical conditioning.
Ivan Pavlov observed that dogs...
2.2K
Managing Impressions01:19

Managing Impressions

Impression management encompasses individuals' deliberate efforts to shape how others perceive them during social interactions. This behavior is often employed to conform to social norms, secure approval, or pursue specific goals. While it involves selective self-presentation, it is not necessarily deceptive; individuals frequently present authentic aspects of themselves that align with situational demands.Common strategies include:Ingratiation: where individuals use flattery or agreeableness...
173
Impression Management Techniques IV: Altercasting01:14

Impression Management Techniques IV: Altercasting

Altercasting is a strategic communication technique in which an individual imposes a specific identity or social role onto another person to influence their behavior and shape the interaction. By presuming a role—such as “responsible leader” or “patient person”—altercasting encourages the target to conform to that identity, often aligning their behavior with the expectations associated with the role. The power of this tactic lies in its subtlety; once a role...
186
Principles of Classical Conditioning01:23

Principles of Classical Conditioning

Classical conditioning, as described by Ivan Pavlov, is a foundational concept in associative learning, where a neutral stimulus becomes capable of eliciting a conditioned response through association with an unconditioned stimulus. The process of acquisition, where this learning occurs, and the subsequent phenomena of contiguity, contingency, generalization, discrimination, extinction, and spontaneous recovery are crucial for a comprehensive understanding of classical conditioning.
During the...
1.9K
Classical Conditioning in Daily Life01:17

Classical Conditioning in Daily Life

Classical conditioning, a fundamental principle of associative learning, explains various phenomena observed in daily life, such as fear development, the placebo effect, taste aversion, and drug habituation. These applications demonstrate the profound impact of associative learning on human behavior and physiological responses.
John B. Watson and Rosalie Rayner famously demonstrated the development of fear through classical conditioning in their experiment with Little Albert. They paired the...
2.2K