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Updated: Feb 4, 2026

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Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies
Published on: April 11, 2012
20.1K
Sepsis Core Measures - Are They Worth the Cost?
Amanda Esposito1, Michael E Silverman1, Frank Diaz1
1Department of Emergency Medicine, Morristown Medical Center, Morristown, New Jersey.
The Journal of Emergency Medicine
|September 27, 2018
Summary
The sepsis core measures did not decrease patient mortality but increased resource use and costs. This study found no significant impact on sepsis survival rates despite increased testing and antibiotic administration.
Area of Science:
- Emergency Medicine
- Critical Care
- Health Services Research
Background:
- Sepsis core measures were implemented in 2015 by CMS and The Joint Commission to reduce sepsis-related morbidity and mortality.
- Emerging evidence questions the efficacy of early goal-directed therapy components underlying these measures.
Purpose of the Study:
- To evaluate resource utilization following the implementation of sepsis core measures.
- To determine if adherence to sepsis core measures impacts patient mortality rates.
Main Methods:
- Retrospective data collection over 3 years in an academic emergency department for patients with suspected sepsis.
- Tracking of laboratory tests (lactates, blood cultures) and antibiotic orders (vancomycin, piperacillin/tazobactam).
- Comparison of sepsis patient mortality rates during 3-month periods each year.
Main Results:
- No significant difference in sepsis patient mortality rates was observed across the 3 study years.
- A notable increase in the administration of piperacillin/tazobactam and vancomycin occurred.
- Significant increases in the number of lactates and blood cultures ordered per patient were recorded.
Conclusions:
- Sepsis core measures did not improve patient mortality rates.
- There was a substantial rise in resource utilization for sepsis care.
- Increased resource use led to higher costs for patients and hospitals without a corresponding mortality benefit.
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