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The multistructural forms of box C/D ribonucleoprotein particles.

Ge Yu1, Yu Zhao2, Hong Li1,2

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RNA (New York, N.Y.)
|September 27, 2018
PubMed
Summary

Structural diversity in archaeal and yeast box C/D ribonucleoprotein particles (RNPs) suggests varied functions beyond rRNA methylation. Key elements like Nop56/58 and box C/D RNA drive these structural and functional differences.

Keywords:
Nop5Nop56Nop58fibrillarinkink-turnrRNA modificationribosome biogenesissnoRNP structures

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Area of Science:

  • Structural biology
  • Molecular biology
  • Biochemistry

Background:

  • Box C/D ribonucleoprotein particles (RNPs) are crucial in cellular processes.
  • Studies in archaea and yeast reveal diverse structures of box C/D RNPs.
  • These diverse structures may indicate a broader range of functional roles than previously understood.

Purpose of the Study:

  • To review known structures of box C/D RNPs.
  • To explore the relationship between structure and function in these particles.
  • To identify key components responsible for structural diversity.

Main Methods:

  • Structural biology techniques (e.g., cryo-EM, X-ray crystallography) were used to determine RNP structures.
  • Comparative analysis of structures from archaeal and yeast systems.
  • Identification of conserved and variable structural elements.

Main Results:

  • A wide array of box C/D RNP structures have been observed in archaea and yeast.
  • Most box C/D RNPs function independently in ribosomal RNA (rRNA) methylation.
  • Some box C/D RNPs are integral components of the small subunit processome involved in rRNA processing.

Conclusions:

  • The Nop56/58 proteins and box C/D RNA are critical determinants of structural diversity in box C/D RNPs.
  • Structural variations likely underpin the diverse functional roles of these ribonucleoprotein complexes.
  • Further research is needed to uncover the full spectrum of box C/D RNP functions.