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The long-term effect of perinatal asphyxia on hippocampal volumes

Kim V Annink1, Linda S de Vries1, Floris Groenendaal1

  • 1Department of Neonatology, Brain Center Rudolf Magnus, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Pediatric Research
|September 27, 2018
PubMed

Insights

Hypoxic-ischemic encephalopathy (HIE) in infants can shrink the hippocampus, impacting memory. Moderate HIE showed smaller hippocampal volumes linked to poorer visuospatial memory in children.

Area of Science:

  • Neuroscience
  • Pediatric Neurology
  • Medical Imaging

Background:

  • Hypoxic-ischemic encephalopathy (HIE) in term-born infants is a significant cause of neurological impairment.
  • The hippocampus plays a crucial role in long-term episodic memory formation.
  • HIE can lead to persistent memory deficits in affected children.

Purpose of the Study:

  • To evaluate the impact of HIE on hippocampal volumes in 9- to 10-year-old children.
  • To explore the relationship between hippocampal volumes and cognitive/memory impairments in children with a history of HIE.

Main Methods:

  • Comparison of hippocampal volumes using 3D-volumetric MRI in children with mild HIE, moderate HIE, and controls.
  • Assessment of intelligence quotient (IQ) and memory functions.
  • Multivariable linear regression to analyze the association between hippocampal volume and memory outcomes.

Main Results:

  • Significantly smaller hippocampal volumes were observed in children with moderate HIE compared to controls.
  • A trend towards reduced hippocampal volumes was noted in children with mild HIE.
  • Reduced hippocampal volume, as a percentage of intracranial volume, was significantly associated with poorer long-term visuospatial memory.

Conclusions:

  • Moderate HIE is associated with reduced hippocampal volumes in school-aged children.
  • Mild HIE may also show a trend towards smaller hippocampal volumes.
  • Hippocampal volume reduction is a potential biomarker for impaired long-term visuospatial memory following HIE.
Abstract

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