Related Experiment Video

Updated: Feb 4, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.7K

Association between polymorphisms in microRNAs and ischemic stroke in an Asian population: evidence based on 6,083

Donghua Zou1, Chunbin Liu1, Qian Zhang1

  • 1Department of Stroke Center, The Fifth Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People's Republic of China, drweijinru@126.com.

Clinical Interventions in Aging
|September 27, 2018
PubMed
Abstract

Insights

Genetic variations in miR-146a and miR-149 are linked to increased ischemic stroke (IS) risk in Asian populations. However, miR-196a2 and miR-499 polymorphisms showed no significant association with IS.

Area of Science:

  • Genetics
  • Molecular Biology
  • Neurology

Background:

  • MicroRNA (miRNA) gene polymorphisms have been implicated in ischemic stroke (IS) pathogenesis.
  • Previous studies on specific miRNA polymorphisms (miR-146a, miR-196a2, miR-149, miR-499) and IS risk have yielded inconsistent findings.

Purpose of the Study:

  • To conduct a meta-analysis investigating the association between four specific miRNA polymorphisms and ischemic stroke risk.
  • To clarify the inconsistent results regarding the role of these polymorphisms in IS susceptibility.

Main Methods:

  • A meta-analysis was performed, pooling data from 14 case-control studies.
  • The analysis included a total of 6,083 IS cases and 7,248 controls from Asian populations.
  • Four polymorphisms (miR-146a rs2910164, miR-196a2 rs11614913, miR-149 rs2292832, miR-499 rs3746444) were assessed across various genetic models.

Main Results:

  • The GG genotype of miR-146a (rs2910164) was associated with an increased risk of IS under the recessive model (OR=1.20, P=0.03).
  • The CC genotype of miR-149 (rs2292832) showed an increased IS risk in both recessive (OR=1.28, P=0.005) and homozygous (OR=1.31, P=0.004) models.
  • No significant association between miR-196a2 (rs11614913) or miR-499 (rs3746444) polymorphisms and IS risk was observed in any genetic model.

Conclusions:

  • The GG genotype of miR-146a and the CC genotype of miR-149 may increase susceptibility to ischemic stroke in Asian populations.
  • Polymorphisms in miR-196a2 and miR-499 do not appear to be associated with IS risk in this population.
  • Further large-scale, well-designed studies are recommended to validate these findings.
Keywords:
ischemic strokemeta-analysismiRNAspolymorphism

More Related Videos

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model07:01

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model

Published on: September 11, 2020

1.9K
Embolic Middle Cerebral Artery Occlusion MCAO for Ischemic Stroke with Homologous Blood Clots in Rats09:11

Embolic Middle Cerebral Artery Occlusion MCAO for Ischemic Stroke with Homologous Blood Clots in Rats

Published on: September 17, 2014

27.8K

Related Concept Videos

The Evidence for Evolution02:55

The Evidence for Evolution

Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
48.3K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.2K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.0K
Conservation of Small Populations02:04

Conservation of Small Populations

Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
17.4K
What is Population Genetics?01:25

What is Population Genetics?

A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
64.8K
Population Growth00:57

Population Growth

Population size is dynamic, increasing with birth rates and immigration, and decreasing with death rates and emigration. In ideal conditions with unlimited resources, populations can increase exponentially, which plots as a J-shaped growth rate curve of population size against time. This type of curve is characteristic of newly-introduced invasive species, or populations that have suffered catastrophic declines and are rebounding.
28.6K