Related Experiment Video

Updated: Feb 4, 2026

Rapid, Safe, and Simple Manual Bedside Nucleic Acid Extraction for the Detection of Virus in Whole Blood Samples
06:59

Rapid, Safe, and Simple Manual Bedside Nucleic Acid Extraction for the Detection of Virus in Whole Blood Samples

Published on: June 30, 2018

7.8K

The Journey of in vivo Virus Engineered Dendritic Cells From Bench to Bedside: A Bumpy Road

Cleo Goyvaerts1, Karine Breckpot1

  • 1Laboratory of Molecular and Cellular Therapy, Department of Biomedical Sciences, Vrije Universiteit Brussel, Jette, Belgium.

Frontiers in Immunology
|September 27, 2018
PubMed

Dendritic cells (DCs) are recognized as highly potent antigen-presenting cells that are able to stimulate cytotoxic T lymphocyte (CTL) responses with antitumor activity. Consequently, DCs have been explored as cellular vaccines in cancer immunotherapy. To that end, DCs are modified with tumor antigens to enable presentation of antigen-derived peptides to CTLs. In this review we discuss the use of viral vectors for in situ modification of DCs, focusing on their clinical applications as anticancer vaccines. Among the viral vectors discussed are those derived from viruses belonging to the families of the Poxviridae, Adenoviridae, Retroviridae, Togaviridae, Paramyxoviridae, and Rhabdoviridae. We will further shed light on how the combination of viral vector-based vaccination with T-cell supporting strategies will bring this strategy to the next level.

Keywords:
T cellcancerdendritic cellimmunotherapypreclinical and clinicalviral vaccine

More Related Videos

In vivo 19F MRI for Cell Tracking10:05

In vivo 19F MRI for Cell Tracking

Published on: November 25, 2013

15.4K
Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber09:55

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Published on: May 30, 2016

9.4K

Related Concept Videos

Design Example: Alignment of a Road Line Using GIS01:17

Design Example: Alignment of a Road Line Using GIS

The alignment of a road line using Geographic Information Systems (GIS) is a critical process in civil engineering, combining advanced technology with practical decision-making. This methodology begins with the collection of geospatial data, including information on land cover, geomorphology, drainage patterns, slope, and contour details. Such data is typically acquired through satellite imagery and GIS tools, offering a comprehensive understanding of the terrain.Once the data is gathered, it...
350
What are Viruses?00:50

What are Viruses?

Overview
128.2K
Neurons: The Cell Body and the Dendrites01:23

Neurons: The Cell Body and the Dendrites

A typical nerve cell comprises three main components: the cell body, dendrites, and the axon. The cell body, also known as the soma or perikaryon, serves as the central biosynthetic hub housing a nucleus surrounded by cytoplasm containing organelles commonly found in most cells. Notably, Nissl bodies, clusters of the rough endoplasmic reticulum and free ribosomes responsible for protein synthesis, are distinctive features of the neuronal cell body. As neurons age, aggregates of a brown pigment...
7.2K
What is Genetic Engineering?00:49

What is Genetic Engineering?

Overview
80.2K
Heat Engines01:10

Heat Engines

A heat engine is a device used to extract heat from a source and then convert it into mechanical work used for various applications. For example, a steam engine on an old-style train can produce the work needed for driving the train.
Whenever we consider heat engines (and associated devices such as refrigerators and heat pumps), we do not use the standard sign convention for heat and work. For convenience, we assume that the symbols Qh, Qc, and W represent only the amounts of heat transferred...
3.7K
Internal Combustion Engine01:20

Internal Combustion Engine

The internal combustion engine is a heat engine that uses the byproducts of combustion as the working fluid instead of using a heat transfer medium to transfer heat. The combustion is done in a way that produces high-pressure combustion products that can be expanded through a turbine or piston to create work. Internal combustion engines can again be categorized into three kinds: (1) spark ignition gasoline engines, most commonly used in automobiles, (2) compression ignition diesel engines that...
2.7K