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Published on: May 10, 2022
Complete androgen insensitivity syndrome and anti-Müllerian hormone levels before and after laparoscopic gonadectomy
Maki Kusumi1, Makiko Mitsunami1, Hiroki Onoue1
1Center of Reproduction and Gynecologic Endoscopic Surgery, Sanno Hospital, Tokyo, Japan.
Abstract:
We report cases of two sisters with complete androgen insensitivity syndrome (CAIS). A complete female appearance, blind-ending vagina, and testes in the pelvis are characteristics of CAIS. Prophylactic laparoscopic gonadectomy was performed in both cases. Anti-Müllerian hormone (AMH) level is known to be very high in patients with CAIS; AMH is secreted by Sertoli cells and testosterone suppresses the secretion. In our cases, serum AMH was very high before gonadectomy and dramatically decreased after gonadectomy. AMH could be the diagnostic feature for patients with CAIS.
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