Effect of Vaginal Estriol Use in Total Laparoscopic Hysterectomy with Gonadotropin-Releasing Hormone Agonist Therapy
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Updated: Feb 4, 2026

Laparoscopic Extracorporeal Knot-Tying for Uterine Vessel Occlusion during Hysterectomy with Cervical Cerclage in Large Uteri
Published on: September 12, 2025
Go Hirata1, Hiroshi Yoshida2, Atsuko Furuno1
1Department of Gynecology, Yokohama City University Medical Center, Yokohama, Kanagawa, Japan.
Study Objectives:
The aim of this study is to evaluate the effects of vaginal estriol therapy in total laparoscopic hysterectomy (TLH) with gonadotropin-releasing hormone agonist (GnRH-a) treatment.
Design:
Retrospective analysis.
Design Classification:
Canadian Task Force classification II-2.
Settings:
Department of Gynecology, Yokohama City University Medical Center, Japan.
Methods:
We retrospectively investigated 50 fibroid cases that had TLH with preoperative GnRH-a treatment and compared the surgical outcome with or without vaginal estriol use (1mg). Estriol was used administered for two weeks before TLH.
Measurements And Main Results:
A total of 12 patients (27%) received vaginal estriol (1 mg) for 14 days before TLH. As a result of vaginal estriol treatment, there were no group differences in uterus size reduction with GnRH-a treatment (22% vs. 15%, P = 0.20), uterine removal time through the vagina (12.5 min vs. 18.5 min, P = 0.18), rate of vaginal dehiscence (3% vs. 0%, P = 0.76) or in the rate of perineal laceration (33% vs. 34%, P = 0.55).
Conclusion:
The use of vaginal estriol treatment before TLH with GnRH-a therapy did not improve surgical outcomes.
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