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Updated: Feb 4, 2026
06:22
Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration
Published on: July 8, 2021
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Five-year development of lumbar disc degeneration-a prospective study
Elina Iordanova Schistad1, Siri Bjorland2,3, Cecilie Røe2,3
1Department of Physical Medicine and Rehabilitation, Oslo University Hospital HF, Ulleval, Postbox 4956, Nydalen, 0424, Oslo, Norway. uxioel@ous-hf.no.
Skeletal Radiology
|September 27, 2018
Summary
Lumbar disc degeneration progression over 5 years is linked to age and baseline degeneration, not genetics. Increased herniated discs correlate with resting pain in patients with back pain.
Area of Science:
- Orthopedics
- Radiology
- Genetics
Background:
- Lumbar disc degeneration is a common cause of low back pain.
- Factors influencing its progression and association with pain require further investigation.
Purpose of the Study:
- To assess the impact of demographic, clinical, and genetic factors on 5-year lumbar disc degeneration.
- To explore links between changes in lumbar degenerative findings and pain.
Main Methods:
- 144 patients with lumbar pain underwent MRI at baseline and 5-year follow-up.
- Disc degeneration, herniated discs, and high-intensity zones were scored.
- Genotyping for VDR, COL11A, MMP1/9, and IL-1α/1RN genes was performed.
Main Results:
- Disc degeneration progression was associated with higher age and less baseline degeneration (p < 0.001).
- No significant associations were found between genetic variants and disc degeneration progression.
- Increased herniated discs over 5 years correlated with pain at rest (p = 0.019).
Conclusions:
- Age and baseline disc degeneration are key factors in 5-year lumbar disc degeneration.
- Genetic factors did not significantly influence disc degeneration development in this cohort.
- Development of herniated discs is associated with resting pain.
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