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Acute fluoxetine differently affects aggressive display in zebrafish phenotypes.

Hellen P Barbosa1, Monica G Lima-Maximino1,2, Caio Maximino2,3,4

  • 1Laboratório de Neurociências e Comportamento "Frederico Guilherme Graeff", Departamento de Morfologia e Ciências Fisiológicas, Campus VIII/Marabá, Universidade do Estado do Pará, Marabá, Pará, Brazil.

Aggressive Behavior
|September 27, 2018
PubMed
Summary

Leopard and longfin zebrafish exhibit distinct aggressive behaviors. Fluoxetine differentially affects aggression in these zebrafish phenotypes, suggesting varied serotonin system roles in aggression.

Keywords:
aggressive displayfluoxetinephenotypic differencesserotoninzebrafish

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Area of Science:

  • Behavioral neuroscience
  • Biological psychiatry
  • Neurobiology of aggression

Background:

  • Zebrafish are increasingly used as a model organism in behavioral neuroscience and biological psychiatry.
  • Studying the neurobiology of aggression in fish broadens research findings.
  • Phenotypic differences between zebrafish strains can elucidate neurobiological mechanisms.

Purpose of the Study:

  • To investigate differences in aggressive displays between leopard and longfin zebrafish phenotypes.
  • To determine the role of phasic serotonin in aggressive displays using zebrafish.
  • To examine the discrepant effects of acute fluoxetine on aggression in different zebrafish populations.

Main Methods:

  • Comparison of mirror-induced aggression between leopard and longfin zebrafish.
  • Administration of acute fluoxetine (2.5 mg/kg and 5 mg/kg) to assess effects on aggressive displays.
  • Measurement of aggression display latency, duration, and frequency.

Main Results:

  • Leopard zebrafish exhibited longer display latencies but lower duration and frequency compared to longfin zebrafish in mirror-induced aggression.
  • Low-dose fluoxetine (2.5 mg/kg) decreased aggression in longfin but not leopard zebrafish.
  • High-dose fluoxetine (5 mg/kg) increased aggression in leopard but not longfin zebrafish.

Conclusions:

  • Longfin zebrafish display greater aggressive motivation and readiness than leopard zebrafish.
  • Acute fluoxetine has opposing effects on aggression in leopard (increases) and longfin (decreases) zebrafish phenotypes.
  • These findings suggest differential roles of the serotonin system in modulating aggression across zebrafish phenotypes.