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Related Experiment Video

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Murine Echocardiography and Ultrasound Imaging
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Three-Dimensional Echocardiography-derived strain values acquired by a novel analysis program.

Xijun Zhang1, Haohui Zhu1, Xinqiao Tian1

  • 1Department of Ultrasonography, The People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Echocardiography (Mount Kisco, N.Y.)
|September 27, 2018
PubMed
Summary

This study validated GE and Philips ultrasound systems for calculating longitudinal strain (LS) after myocardial infarct (MI) using TomTec software. Both systems showed decreased LS post-MI, correlating well with sonomicrometry data.

Keywords:
longitudinal strain valuesthree-dimensional speckle-tracking echocardiography

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Area of Science:

  • Cardiovascular Imaging
  • Echocardiography
  • Cardiac Mechanics

Background:

  • Longitudinal strain (LS) is a key echocardiographic parameter for assessing myocardial function.
  • Vendor-specific analysis software can introduce variations in LS measurements.
  • Validation of vendor-independent software across different ultrasound systems is crucial for reliable clinical application.

Purpose of the Study:

  • To validate the variation in longitudinal strain (LS) measurements between two ultrasound systems (GE Vivid E9 and Philips IE 33) after myocardial infarct (MI).
  • To assess the performance of a vendor-independent analysis software (TomTec's 4D LV Analysis) for LS calculation.
  • To compare echocardiographic LS measurements with sonomicrometry data.

Main Methods:

  • In vitro study using ten porcine hearts.
  • Acquisition of 3D echocardiography (3DE) data before and after induced myocardial infarct (MI).
  • LS calculation using TomTec's 4D LV Analysis software and validation against sonomicrometry.

Main Results:

  • Excellent correlations were observed between TomTec-calculated LS and sonomicrometry data for both ultrasound systems (R² ≈ 0.70).
  • Both systems showed decreased LS after MI, with an average reduction of approximately 30% for GE and 25% for Philips.
  • Bland-Altman analysis indicated a slight overestimation of echo-derived strain values.

Conclusions:

  • GE and Philips echocardiographic systems are suitable for analysis with TomTec's 4D LV Analysis software.
  • The software provides reliable LS measurements that correlate well with sonomicrometry, exhibiting acceptable variations.
  • This validates the use of vendor-independent software for consistent strain analysis across different echocardiographic platforms.