Related Experiment Video
Updated: Feb 4, 2026
A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli
Published on: August 12, 2016
Considering Blood Dilution improves the Precision of Continuous Whole Blood Glucose Measurements
Carsten Benesch1, Mareike Kuhlenkötter1, Tim Heise1
11 Profil, Neuss, Germany.
Background:
One major advantage of automated over manual clamps are continuous measurements of blood glucose concentrations (BG) allowing frequent adaptations in glucose infusion rates (GIR). However, BG measurements might be affected by changes in blood dilution. ClampArt®, a modern automated clamp device, corrects BG measurements for blood dilution, but the impact of this correction is unclear.
Methods:
The authors performed a retrospective analysis of BG during glucose clamps comparing values with a fixed dilution factor with those corrected for the actual blood dilution.
Results:
Clamp quality substantially improved with the consideration of blood dilution: Mean accuracy fell from 8.1% ± 2.9% to 4.1% ± 0.8%, precision improved from 9.6 ± 3.6 mg/dl to 3.7 ± 1.3 mg/dl and control deviation from -2.6 ± 4.2 mg/dl to 0.2 ± 0.2 mg/dl.
Conclusions:
Correcting continuous BG measurements for blood dilution significantly increases BG measurement and clamp quality.
More Related Videos
Related Concept Videos
01:02Glucose Homeostasis: Regulation of Blood Glucose
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
01:16Hormones Regulating Blood Glucose
In addition to accelerating glucose uptake and utilization, insulin has...
01:17Measurement of Blood Pressure
03:37Uncertainty in Measurement: Accuracy and Precision
01:30Equipments Used To Measure Blood Pressure
This invasive approach involves cannulating a peripheral artery. During each cardiac contraction, pressure generates mechanical motion within the catheter, transmitted through rigid, fluid-filled tubing to a transducer. This transducer converts mechanical motion into electrical signals displayed as waveforms on a monitor. An automatic flushing system prevents blood backflow. Due to the potential risk of unexpected arterial blood loss, this method is primarily used in intensive...
01:28Special considerations while measuring blood pressure
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.