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Updated: Feb 4, 2026

Targeted Expression of GFP in the Hair Follicle Using Ex Vivo Viral Transduction
Published on: March 17, 2008
Embryonic-like regenerative phenomenon: wound-induced hair follicle neogenesis
Lin Gong1, Xue-Gang Xu1, Yuan-Hong Li1
1Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang 110001, PR China.
Abstract:
Wound-induced hair follicle neogenesis (WIHN) is a regenerative phenomenon that occurs widely in the skin of adult mammalians. A fully functional follicle can regenerate in the center of a full-thickness wound with a large enough size. The cellular origin of this process is similar to embryonic process. Many growth and development-related pathways are involved in WIHN. Studying WIHN can deeply explore the mechanism of biological growth, development and regeneration, and can identify new treatments for hair-related disorders. Our review aims to enlighten future study by summarizing the clinical manifestation of WIHN, as well as the cellular and molecular mechanism of WIHN in recent studies.
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